Meta-Analysis: The Value of Clinical Assessment in the Diagnosis of Deep Venous Thrombosis

  1. Steve Goodacre, MB, ChB, FFAEM, MSc, PhD;
  2. Alex J. Sutton, BSc, MSc, PhD; and
  3. Fiona C. Sampson, BA, MSc
  1. From University of Sheffield, Sheffield, and University of Leicester, Leicester, United Kingdom.
    1. Figure 1. *κ = 0.85. †κ = 0.86.
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      Figure 1. *κ = 0.85. †κ = 0.86. Flow diagram of studies considered for the review.
    2. Figure 2.
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      Figure 2. Meta-analysis estimates of diagnostic value of clinical features of deep venous thrombosis (DVT).
    3. Figure 3.
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      Figure 3. Post-test probability of deep venous thrombosis after high or low Wells scores as a function of pretest probability (population prevalence of deep venous thrombosis).
    4. Figure 4. Two results are plotted from each study of the Wells score on the receiver-operating characteristic plane. Circles represent use of a high versus intermediate and low decision threshold (that is, only persons categorized as at high risk receive a diagnosis of deep venous thrombosis). Triangles represent a high and intermediate versus low decision threshold (that is, persons categorized as at high or intermediate risk receive a diagnosis of deep venous thrombosis). The point estimates and 95% CIs for pooled sensitivity and specificity for the 2 thresholds are also plotted as boxes.
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      Figure 4. Two results are plotted from each study of the Wells score on the receiver-operating characteristic plane. Circles represent use of a high versus intermediate and low decision threshold (that is, only persons categorized as at high risk receive a diagnosis of deep venous thrombosis). Triangles represent a high and intermediate versus low decision threshold (that is, persons categorized as at high or intermediate risk receive a diagnosis of deep venous thrombosis). The point estimates and 95% CIs for pooled sensitivity and specificity for the 2 thresholds are also plotted as boxes. Performance of the Wells clinical risk score for detecting all episodes of deep venous thrombosis.

    Summary for Patients

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