The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial

  1. Trevor J. Orchard, MD;
  2. Marinella Temprosa, MS;
  3. Ronald Goldberg, MD;
  4. Steven Haffner, MD;
  5. Robert Ratner, MD;
  6. Santica Marcovina, PhD, DSc;
  7. Sarah Fowler, PhD; and
  8. for the Diabetes Prevention Program Research Group
  1. From the Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, Rockville, Maryland.
    1. Figure 1.
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      Figure 1. Randomly assigned participants by treatment group and annual visit.
    2. Figure 2.
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      Figure 2. Development of the metabolic syndrome by intervention group in the Diabetes Prevention Program.
    3. Figure 3.
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      Figure 3. Resolution of the metabolic syndrome by intervention group in the Diabetes Prevention Program.
    4. Appendix Figure. Numbers are numbers of participants at baseline. The shaded sections represent participants meeting the metabolic syndrome criteria as defined by the National Cholesterol Education Program Adult Panel II. BP = blood pressure; HDL-C = high-density lipoprotein cholesterol; TG = triglyceride.
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      Appendix Figure. Numbers are numbers of participants at baseline. The shaded sections represent participants meeting the metabolic syndrome criteria as defined by the National Cholesterol Education Program Adult Panel II. BP = blood pressure; HDL-C = high-density lipoprotein cholesterol; TG = triglyceride. Venn diagram of the components of the metabolic syndrome.Graphic

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