Table of Contents

March 15, 2005; 142 (6)

Articles

  • Relative Importance of Borderline and Elevated Levels of Coronary Heart Disease Risk Factors

    • Ramachandran S. Vasan,
    • Lisa M. Sullivan,
    • Peter W.F. Wilson,
    • Christopher T. Sempos,
    • Johan Sundström,
    • William B. Kannel,
    • Daniel Levy,
    • and Ralph B. D'Agostino
    Ann Intern Med March 15, 2005 142:393-402

    These researchers estimated the 10-year coronary heart disease event rate for each person in a nationally representative sample by using the individual's risk factors and the Framingham Study risk equation. The findings suggest that in the United States, borderline levels of risk factors account for a small proportion of coronary heart disease events.

  • Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes

    • Guenther Boden,
    • Karin Sargrad,
    • Carol Homko,
    • Maria Mozzoli,
    • and T. Peter Stein
    Ann Intern Med March 15, 2005 142:403-411

    In a small group of obese, diabetic patients, 2 weeks of a low-carbohydrate diet led to spontaneous reduction in energy intake because, despite the carbohydrate restriction, the participants did not increase their fat and protein intake. Twenty-four-hour blood glucose profiles, insulin sensitivity, and hemoglobin A1c values all improved.

  • Thyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Comparing l-Thyroxine plus Liothyronine with l-Thyroxine Alone

    • Héctor F. Escobar-Morreale,
    • José I. Botella-Carretero,
    • Manuel Gómez-Bueno,
    • José M. Galán,
    • Vivencio Barrios,
    • and José Sancho
    Ann Intern Med March 15, 2005 142:412-424

    The authors gave women with overt primary hypothyroidism combinations of l-thyroxine (synthetic T4) plus liothyronine (synthetic T3) in doses that mimic the normal secretion of the thyroid gland. Even though combination therapy did not offer any objective advantage over l-thyroxine alone, the patients preferred it.

  • C-Reactive Protein Levels Are Not Associated with Increased Risk for Colorectal Cancer in Women

    • Shumin M. Zhang,
    • Julie E. Buring,
    • I-Min Lee,
    • Nancy R. Cook,
    • and Paul M. Ridker
    Ann Intern Med March 15, 2005 142:425-432

    Contrary to a recent large study, elevated plasma C-reactive protein levels were not associated with an increased risk for developing colorectal cancer in apparently healthy women. The results suggest that low-grade inflammation does not play an important role in increasing the risk for colorectal cancer.

Updates

  • Update in Nephrology and Hypertension

    • Donald G. Vidt
    Ann Intern Med March 15, 2005 142:433-438

    This year's Update in Nephrology and Hypertension incorporates articles on clinical hypertension; proteinuria, lipids, and renal disease; blood pressure, angiotensin II antagonists, and renal disease; smoking and renal disease; hypertension and coronary artery disease; and chronic kidney disease detection.

Reviews

  • Recommendations for the Diagnosis and Treatment of the Acute Porphyrias

    • Karl E. Anderson,
    • Joseph R. Bloomer,
    • Herbert L. Bonkovsky,
    • James P. Kushner,
    • Claus A. Pierach,
    • Neville R. Pimstone,
    • and Robert J. Desnick
    Ann Intern Med March 15, 2005 142:439-450

    The authors review the clinical manifestations, pathophysiology, and genetics of the acute porphyrias and provide advice about diagnosis and treatment based on the clinical literature and their experience.

  • Meta-Analysis: Methods for Diagnosing Intravascular Device–Related Bloodstream Infection

    • Nasia Safdar,
    • Jason P. Fine,
    • and Dennis G. Maki
    Ann Intern Med March 15, 2005 142:451-466

    Paired quantitative blood culture is the most accurate test for diagnosis of intravascular device–related bloodstream infection. However, most other methods studied showed acceptable sensitivity and specificity (both > 0.75). Physicians should culture catheters only if they suspect intravascular device–related bloodstream infection.

Editorials

  • The Middle-Aged and Older American: Wrong Prototype for a Preventive Polypill?

    • Cynthia Mulrow and
    • William Kussmaul
    Ann Intern Med March 15, 2005 142:467-468

    Researchers have proposed that physicians should advise all of their patients over age 55 to take a polypill containing treatments for many cardiovascular risk factors rather than testing them for risk factors and treating selectively. In this issue, Vasan and colleagues describe the prevalence of risk factors for cardiovascular disease in the United States. This evidence, along with other data, suggests that a preventive polypill is the wrong approach for this population.

  • Is There Something Special about Low-Carbohydrate Diets?

    • George A. Bray
    Ann Intern Med March 15, 2005 142:469-470

    In this issue, Boden and colleagues show that the reduction in energy intake during very-low-carbohydrate diets accounts for the observed weight loss. The explanation for weight loss after restricting carbohydrate applies to many different diets. Because weight loss during a diet usually plateaus after a while, patients may benefit from switching between diets with different approaches to food restriction.

Letters

  • When Most Doctors Are Women

    • Evelyn V. Hess
    Ann Intern Med March 15, 2005 142:471

  • Breast Cancer after Childhood Cancer

    • Gabriele Rossi
    Ann Intern Med March 15, 2005 142:471

  • Breast Cancer after Childhood Cancer

    • James M. Howard
    Ann Intern Med March 15, 2005 142:471-472

  • Breast Cancer after Childhood Cancer

    • Lisa B. Kenney
    Ann Intern Med March 15, 2005 142:472

  • Evidence for Expanding Physician Supply

    • W. Bruce Fye
    Ann Intern Med March 15, 2005 142:472-473

  • Evidence for Expanding Physician Supply

    • Vincent M. Pedre III
    Ann Intern Med March 15, 2005 142:473

  • Evidence for Expanding Physician Supply

    • William A. Curry and
    • Clyde Barganier
    Ann Intern Med March 15, 2005 142:473

  • Evidence for Expanding Physician Supply

    • Sharon I.S. Rounds and
    • Derek C. Angus
    Ann Intern Med March 15, 2005 142:473-474

  • Evidence for Expanding Physician Supply

    • Richard A. Cooper
    Ann Intern Med March 15, 2005 142:474

  • Drug-Induced Thrombocytopenia: An Updated Systematic Review

    • Xiaoning Li,
    • Laura Hunt,
    • and Sara K. Vesely
    Ann Intern Med March 15, 2005 142:474-475

  • Sarcoidosis Presenting with Massive Involvement of the Nervous System

    • Salvatore Sollima,
    • Francesco Croce,
    • Chiara Scalamogna,
    • Ilaria Caramma,
    • and Spinello Antinori
    Ann Intern Med March 15, 2005 142:475-476

  • Rapid Diagnostic Test for Plasmodium falciparum in 32 Marines Medically Evacuated from Liberia with a Febrile Illness

    • Brian Susi,
    • Tim Whitman,
    • David L. Blazes,
    • Timothy H. Burgess,
    • Gregory J. Martin,
    • and Daniel Freilich
    Ann Intern Med March 15, 2005 142:476-477

  • Two Patients with Acute Liver Injury Associated with Use of the Herbal Weight-Loss Supplement Hydroxycut

    • Tyler Stevens,
    • Asif Qadri,
    • and Nizar N. Zein
    Ann Intern Med March 15, 2005 142:477-478

  • Choreoathetosis with Dopamine

    • Victoria A. Walker and
    • Maryam Massoumi
    Ann Intern Med March 15, 2005 142:478-479

  • Correction: Office-Based Testing for Fecal Occult Blood

    Ann Intern Med March 15, 2005 142:479

  • Correction: Prolonged Coagulopathy Related to Superwarfarin Overdose

    Ann Intern Med March 15, 2005 142:479

Medical Writings: Book Notes

  • Creative Healers: A Collection of Essays, Reviews, and Poems from The Pharos 1938-1998

    • Judith Overmier
    Ann Intern Med March 15, 2005 142:480

  • Sleep Deprivation: Clinical Issues, Pharmacology, and Sleep Loss Effects

    • Thomas F. Mulrooney
    Ann Intern Med March 15, 2005 142:480

Medical Notices

  • Medical Notices

    Ann Intern Med March 15, 2005 142:0

Summaries for Patients

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This Issue

March 15, 2005; 142 (6)
  1. Articles
  2. Updates
  3. Reviews
  4. Editorials
  5. Letters
  6. Medical Writings: Book Notes
  7. Medical Notices
  8. Summaries for Patients

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