Screening for Abdominal Aortic Aneurysm: A Best-Evidence Systematic Review for the U.S. Preventive Services Task Force

  1. Craig Fleming, MD;
  2. Evelyn P. Whitlock, MD, MPH;
  3. Tracy L. Beil, MS; and
  4. Frank A. Lederle, MD
  1. From Oregon Evidence-based Practice Center and Center for Health Research, Kaiser Permanente, Portland, Oregon; and Center for Epidemiological and Clinical Research, Veterans Affairs Medical Center, Minneapolis, Minnesota.
    1. Figure 1. MASS = Multicentre Aneurysm Screening Study; OR = odds ratio.
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      Figure 1. MASS = Multicentre Aneurysm Screening Study; OR = odds ratio. Meta-analysis of mortality associated with abdominal aortic aneurysms in the abdominal aortic aneurysm screening trials.
    2. Figure 2. MASS = Multicentre Aneurysm Screening Study; OR = odds ratio. *Age = standardized numbers were used for the Western Australia trial because of an early age imbalance that was subsequently corrected .
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      Figure 2. MASS = Multicentre Aneurysm Screening Study; OR = odds ratio. *Age = standardized numbers were used for the Western Australia trial because of an early age imbalance that was subsequently corrected . Meta-analysis of all-cause mortality in the abdominal aortic aneurysm screening trials.(24)
    3. Figure 3.
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      Figure 3. Prevalence of abdominal aortic aneurysms (AAAs) greater than 3.0 cm, according to age and smoking history.
    4. Appendix Figure 1. KQ = key question. KQ 1a = Does AAA screening, in an asymptomatic average-risk or high-risk population, reduce AAA-related adverse health outcomes? KQ 1b = For individuals who do not have AAAs on initial screening, does periodic repeated screening reduce AAA-related adverse health outcomes? KQ 2 = What are the harms associated with AAA screening? KQ 3 = For AAAs 3.0 to 5.4 cm detected through screening, does immediate repair or surveillance reduce AAA-related adverse health outcomes? KQ 4 = What are the harms associated with repair of AAAs 5.5 cm or greater? KQ 5 = What are the harms associated with immediate repair or surveillance of AAAs 3.0 to 5.4 cm?
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      Appendix Figure 1. KQ = key question. KQ 1a = Does AAA screening, in an asymptomatic average-risk or high-risk population, reduce AAA-related adverse health outcomes? KQ 1b = For individuals who do not have AAAs on initial screening, does periodic repeated screening reduce AAA-related adverse health outcomes? KQ 2 = What are the harms associated with AAA screening? KQ 3 = For AAAs 3.0 to 5.4 cm detected through screening, does immediate repair or surveillance reduce AAA-related adverse health outcomes? KQ 4 = What are the harms associated with repair of AAAs 5.5 cm or greater? KQ 5 = What are the harms associated with immediate repair or surveillance of AAAs 3.0 to 5.4 cm? Primary care screening for abdominal aortic aneurysms (AAAs): analytic framework.Graphic
    5. Appendix Figure 2. All abstracts were reviewed for relevance to other KQs. Articles from experts or reference lists were also reviewed if relevant.
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      Appendix Figure 2. All abstracts were reviewed for relevance to other KQs. Articles from experts or reference lists were also reviewed if relevant. Trial flow diagram of studies evaluated for inclusion in each key question (KQ).Graphic

    Summary for Patients

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