Challenges in Systematic Reviews of Therapeutic Devices and Procedures

  1. Lisa Hartling, MSc;
  2. Finlay A. McAlister, MD, MSc;
  3. Brian H. Rowe, MD, MSc;
  4. Justin Ezekowitz, MB, BCh, MSc;
  5. Carol Friesen, MA, MLIS; and
  6. Terry P. Klassen, MD, MSc
  1. From The University of Alberta/Capital Health Evidence-based Practice Center and the University of Alberta, Edmonton, Canada.
    1. Figure 1. The distribution of results indicates systematic bias (average odds ratios in the randomized, controlled trials and historical controlled studies were 1.23 and 1.06, respectively). Adapted with permission from reference : Deeks JJ, Dinnes J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, et al. Evaluating non-randomised intervention studies. Health Technol Assess. 2003;7:iii-x, 1-173.
      View larger version:
      Figure 1. The distribution of results indicates systematic bias (average odds ratios in the randomized, controlled trials and historical controlled studies were 1.23 and 1.06, respectively). Adapted with permission from reference : Deeks JJ, Dinnes J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, et al. Evaluating non-randomised intervention studies. Health Technol Assess. 2003;7:iii-x, 1-173. Comparison of the results of 8000 randomized, controlled trials (RCTs) and 8000 historical controlled studies (HCTs) obtained from resampling within the European Carotid Surgery Trial.27
    2. Figure 2. The distribution of results revealed that 9% of studies within each design had statistically significant findings. Adapted with permission from reference : Deeks JJ, Dinnes J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, et al. Evaluating non-randomised intervention studies. Health Technol Assess. 2003;7:iii-x, 1-173.
      View larger version:
      Figure 2. The distribution of results revealed that 9% of studies within each design had statistically significant findings. Adapted with permission from reference : Deeks JJ, Dinnes J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, et al. Evaluating non-randomised intervention studies. Health Technol Assess. 2003;7:iii-x, 1-173. Comparison of the results of 8000 randomized, controlled trials (RCTs) and 8000 concurrently controlled trials (CCTs) obtained from resampling within the European Carotid Surgery Trial.27
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    1. Ann Intern Med June 21, 2005 vol. 142 no. 12 Part 2 1100-1111
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