Challenges in Systematic Reviews That Evaluate Drug Efficacy or Effectiveness

  1. P. Lina Santaguida, PhD;
  2. Mark Helfand, MD, MPH; and
  3. Parminder Raina, PhD
  1. From McMaster University Evidence-based Practice Centre, Hamilton, Ontario, Canada; and Portland Veterans Affairs Medical Center and Oregon Health & Science University Evidence-based Practice Center, Portland, Oregon.
    1. Figure 1.
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        Figure 1. Delay in effects of symptomatic treatment.
      • Figure 2.
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          Figure 2. Delay in effects of disease-progression treatment.
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