Table of Contents

June 21, 2005; 142 (12 Part 1)

Articles

  • The Effect of Combined Estrogen and Progesterone Hormone Replacement Therapy on Disease Activity in Systemic Lupus Erythematosus: A Randomized Trial

    • Jill P. Buyon,
    • Michelle A. Petri,
    • Mimi Y. Kim,
    • Kenneth C. Kalunian,
    • Jennifer Grossman,
    • Bevra H. Hahn,
    • Joan T. Merrill,
    • Lisa Sammaritano,
    • Michael Lockshin,
    • Graciela S. Alarcón,
    • Susan Manzi,
    • H. Michael Belmont,
    • Anca D. Askanase,
    • Lisa Sigler,
    • Mary Anne Dooley,
    • Joan Von Feldt,
    • W. Joseph McCune,
    • Alan Friedman,
    • Jane Wachs,
    • Mary Cronin,
    • Michelene Hearth-Holmes,
    • Mark Tan,
    • and Frederick Licciardi
    Ann Intern Med June 21, 2005 142:(Supplement 1) 953-962

    Hormone replacement therapy (HRT) allegedly worsens disease activity in women with systemic lupus erythematosus (SLE). This randomized, controlled trial evaluated the effect of HRT on disease activity in postmenopausal women with SLE. Adding a short course of HRT causes a small increase in flares of lupus. Most flares are mild to moderate.

  • The Clinical Course of Patients with Idiopathic Pulmonary Fibrosis

    • Fernando J. Martinez,
    • Sharon Safrin,
    • Derek Weycker,
    • Karen M. Starko,
    • Williamson Z. Bradford,
    • Talmadge E. King, Jr,
    • Kevin R. Flaherty,
    • David A. Schwartz,
    • Paul W. Noble,
    • Ganesh Raghu,
    • Kevin K. Brown,
    • and for the IPF Study Group*
    Ann Intern Med June 21, 2005 142:(Supplement 1) 963-967

    This study examined the clinical course of 168 patients with mild to moderate idiopathic pulmonary fibrosis. Physiologic variables changed minimally, but 21% of patients died. Acute clinical deterioration preceded death in 47% of decedents. Acute deterioration in mild to moderate disease is an ominous sign of the need for referral for lung transplantation.

  • An Electrocardiogram-Based Algorithm To Detect Loss of Left Ventricular Capture during Cardiac Resynchronization Therapy

    • Peter Ammann,
    • Christian Sticherling,
    • Dietrich Kalusche,
    • Jens Eckstein,
    • Alain Bernheim,
    • Beat Schaer,
    • and Stefan Osswald
    Ann Intern Med June 21, 2005 142:(Supplement 1) 968-973

    Cardiac resynchronization devices use a bipolar electrode to depolarize the right and left ventricles synchronously. Loss of left ventricular capture may cause worsening heart failure and can be difficult to diagnose without special equipment. An algorithm that analyzes the R–S ratio on leads V1 and I of the surface electrocardiogram accurately diagnoses failure to capture the left ventricle.

Review

  • Meta-Analysis: Antibiotic Prophylaxis Reduces Mortality in Neutropenic Patients

    • Anat Gafter-Gvili,
    • Abigail Fraser,
    • Mical Paul,
    • and Leonard Leibovici
    Ann Intern Med June 21, 2005 142:(Supplement 1) 979-995

    The authors examined 95 randomized, controlled trials of antibiotic prophylaxis in afebrile neutropenic patients. Antibiotic prophylaxis for neutropenic patients undergoing cytotoxic therapy reduced mortality, especially with fluoroquinolones. Physicians should consider giving antibiotic prophylaxis, preferably with a fluoroquinolone, to neutropenic patients.

Perspectives

  • Independent Medical Examinations: An Expanding Source of Physician Liability

    • Ken Baum
    Ann Intern Med June 21, 2005 142:(Supplement 1) 974-978

    Employers often ask physicians to examine employees or review their diagnostic test results. These services are commonly called independent medical examinations. Given the current medical malpractice climate, physicians must understand their potential liability when doing independent medical examinations. This article summarizes the law and offers suggestions for limiting liability.

Medicine and Public Issues

  • High and Rising Health Care Costs. Part 3: The Role of Health Care Providers

    • Thomas Bodenheimer
    Ann Intern Med June 21, 2005 142:(Supplement 1) 996-1002

    The market power of physicians and health systems is one commonly held explanation for high and rising health care costs in the United States. This third article of a 4-part series examines how the prices and the quantity of health care services interact to influence health care expenditures. The article also reviews cost-containment strategies to reduce prices and quantities of services.

Editorials

  • Help for Menopausal Patients with Lupus?

    • Evelyn V. Hess
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1014-1015

    Patients with lupus have menopause-related symptoms, and some need hormone replacement therapy to gain relief. This randomized trial compared the rate of serious flares of lupus during 12 months of estrogen and progesterone therapy or placebo. Hormone replacement increases the rate of flares by a small amount that some women may find acceptable in order to gain relief from their menopausal symptoms.

  • Annals 2004–2005: A Peek Back and a Look Forward

    • The Editors
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1016-1018

    July marks the first issue of a new volume of Annals. The transition from volume 142 to 143 seems an appropriate time to reflect on the journal's health, review new features begun in the past several months, discuss developments on the horizon, and share our wish list of different types of articles that we would like to see coming over the transom.

  • Reviews: Making Sense of an Often Tangled Skein of Evidence

    • The Editors
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1019-1020

    Annals places a high priority on publishing up-to-date summative articles because we believe that they should shape standards for clinical practice. This editorial offers advice to authors of reviews. In an accompanying supplement (part 2 of this issue), authors from the North American Evidence-based Practice Centers offer detailed advice on doing systematic reviews, compiling evidence reports, and handling the methodologic challenges of systematic reviews.

On Being a Doctor

  • One in Three

    • David Malebranche
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1021-1022

    A few years ago, the Centers for Disease Control and Prevention reported that one out of every three black men who have sex with men are HIV positive. Since I am a physician who happens to be both black and homosexual, I belong to this risk group. For me, getting an HIV test is a yearly ritual—it's something many black men who have sex with men do because of the fear embedded in our psyches for simply being who we are.

Letters

  • Patient Self-Management of Oral Anticoagulation

    • Benton M. Wheeler III
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1023

  • Patient Self-Management of Oral Anticoagulation

    • Juan Carlos Souto,
    • Bárbara Menéndez-Jándula,
    • and Jordi Fontcuberta
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1023

  • Commercial Weight Loss Programs

    • Linda Gotthelf
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1023-1024

  • Commercial Weight Loss Programs

    • Adam Gilden Tsai and
    • Thomas A. Wadden
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1024-1025

  • Aggressive Treatment of High-Density Lipoprotein Cholesterol

    • Stephen J. Nicholls
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1025

  • Aggressive Treatment of High-Density Lipoprotein Cholesterol

    • Richard A. Krasuski and
    • Edwin J. Whitney
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1025-1026

  • Cognitive Psychology of Missed Diagnoses

    • David D. Derauf
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1026

  • Cognitive Psychology of Missed Diagnoses

    • Donald A. Redelmeier
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1026

  • A New Concept of Unopposed β-Adrenergic Overstimulation in a Patient with Pheochromocytoma

    • Vitaly Kantorovich and
    • Karel Pacak
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1026-1028

Current Clinical Issues

  • Liver Cancer on the Rise

    • Jennifer Fisher Wilson
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1029-1032

Summaries for Patients

  • Hormone Replacement Therapy Does Not Increase Severe Lupus Flares

    Ann Intern Med June 21, 2005 142:(Supplement 1) I-22

  • What Is the Natural Course of Idiopathic Pulmonary Fibrosis?

    Ann Intern Med June 21, 2005 142:(Supplement 1) I-23

  • Using Electrocardiography To Detect Problems with Cardiac Resynchronization Devices

    Ann Intern Med June 21, 2005 142:(Supplement 1) I-24

NIH Conferences

  • National Institutes of Health State-of-the-Science Conference Statement: Management of Menopause-Related Symptoms

    • NIH State-of-the-Science Panel*
    Ann Intern Med June 21, 2005 142:(Supplement 1) 1003-1013

    Women and their health care providers need to know the safest and most effective medical and nonmedical treatments for menopausal symptoms. To address this need, the National Institute on Aging and the Office of Medical Applications of Research of the National Institutes of Health sponsored a State-of-the-Science Conference on Management of Menopause-Related Symptoms on 21–23 March 2005, in Bethesda, Maryland. This state-of-the-science statement answers the 5 key questions posed at the conference.

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This Issue

June 21, 2005; 142 (12 Part 1)
  1. Articles
  2. Review
  3. Perspectives
  4. Medicine and Public Issues
  5. Editorials
  6. On Being a Doctor
  7. Letters
  8. Current Clinical Issues
  9. Summaries for Patients
  10. NIH Conferences

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