Table of Contents

September 21, 2004; 141 (6)

Articles

  • Association of Hemoglobin A1c with Cardiovascular Disease and Mortality in Adults: The European Prospective Investigation into Cancer in Norfolk

    • Kay-Tee Khaw,
    • Nicholas Wareham,
    • Sheila Bingham,
    • Robert Luben,
    • Ailsa Welch,
    • and Nicholas Day
    Ann Intern Med September 21, 2004 141:413-420

    In this study of patients recruited from general practice, the risk for cardiovascular disease and total mortality rose continuously throughout the range of hemoglobin A1c concentrations seen in the general population. Seventy-five percent of the excess population mortality risk associated with a hemoglobin A1c concentration greater than 5.0% occurred in persons with concentrations between 5.0% and 6.9%.

  • Meta-Analysis: Glycosylated Hemoglobin and Cardiovascular Disease in Diabetes Mellitus

    • Elizabeth Selvin,
    • Spyridon Marinopoulos,
    • Gail Berkenblit,
    • Tejal Rami,
    • Frederick L. Brancati,
    • Neil R. Powe,
    • and Sherita Hill Golden
    Ann Intern Med September 21, 2004 141:421-431

    This meta-analysis of observational studies in patients with diabetes shows that increased serum hemoglobin A1c levels are associated with an increased risk for cardiovascular disease in both type 1 and type 2 diabetes.

  • Manipulative Therapy in Addition to Usual Medical Care for Patients with Shoulder Dysfunction and Pain: A Randomized, Controlled Trial

    • Gert J.D. Bergman,
    • Jan C. Winters,
    • Klaas H. Groenier,
    • Jan J.M. Pool,
    • Betty Meyboom-de Jong,
    • Klaas Postema,
    • and Geert J.M.G. van der Heijden
    Ann Intern Med September 21, 2004 141:432-439

    This trial compared manipulative therapy plus usual care for shoulder dysfunction and pain with usual care alone. Manipulative therapy appears to be an effective treatment option for patients with shoulder pain that is not due to trauma, fracture, rupture, or dislocation.

  • Comparison of Clinical Criteria for the Acute Respiratory Distress Syndrome with Autopsy Findings

    • Andrés Esteban,
    • Pilar Fernández-Segoviano,
    • Fernando Frutos-Vivar,
    • José Antonio Aramburu,
    • Laura Nájera,
    • Niall D. Ferguson,
    • Inmaculada Alía,
    • Federico Gordo,
    • and Fernando Ríos
    Ann Intern Med September 21, 2004 141:440-445

    As measured in a series of autopsied patients with suspected acute respiratory distress syndrome, the American–European Consensus Conference definition did not detect 25% of patients with this syndrome (sensitivity, 75%). Among patients who did not have this syndrome at autopsy, 16% satisfied the diagnostic criteria (specificity, 84%).

Improving Patient Care

  • Improvements in 1-Year Cardiovascular Clinical Outcomes Associated with a Hospital-Based Discharge Medication Program

    • Jason M. Lappé,
    • Joseph B. Muhlestein,
    • Donald L. Lappé,
    • Rodney S. Badger,
    • Tami L. Bair,
    • Ruth Brockman,
    • Thomas K. French,
    • Linda C. Hofmann,
    • Benjamin D. Horne,
    • Susan Kralick-Goldberg,
    • Nan Nicponski,
    • Janette A. Orton,
    • Robert R. Pearson,
    • Dale G. Renlund,
    • Holly Rimmasch,
    • Colleen Roberts,
    • and Jeffrey L. Anderson
    Ann Intern Med September 21, 2004 141:446-453

    The authors introduced a program to increase prescribing of appropriate discharge medications to patients with cardiovascular disease in an integrated multihospital system. In this nonrandomized before–after study, the program was associated with a 19% reduction in cardiovascular mortality 1 year after discharge.

Updates

  • Update in Oncology

    • Steven H. Stein
    Ann Intern Med September 21, 2004 141:454-459

    This year's Update in Oncology incorporates articles on breast cancer, lung cancer, the immune response, prostate cancer, multiple myeloma, and colon cancer.

Review

  • The Acute Respiratory Distress Syndrome

    • Claude A. Piantadosi and
    • David A. Schwartz
    Ann Intern Med September 21, 2004 141:460-470

    This review describes the clinical, etiologic, and physiologic basis of the acute respiratory distress syndrome and summarizes how its molecular pathogenesis leads to respiratory failure. The authors describe a physiologic basis for the respiratory management of patients with this syndrome.

Perspectives

  • When Most Doctors Are Women: What Lies Ahead?

    • Wendy Levinson and
    • Nicole Lurie
    Ann Intern Med September 21, 2004 141:471-474

    The profession of medicine is becoming feminized as the number of women entering medicine has increased over the past several decades. The authors predict notable changes in 4 domains: the patient–physician relationship, the local delivery of care, the societal delivery of care, and the medical profession itself.

Editorials

  • Glycosylated Hemoglobin: Finally Ready for Prime Time as a Cardiovascular Risk Factor

    • Hertzel C. Gerstein
    Ann Intern Med September 21, 2004 141:475-476

    What can we conclude from the reports by Khaw and Selvin and colleagues in this issue? First, the glycosylated hemoglobin level is an independent progressive risk factor for cardiovascular events, regardless of diabetes status. Second, glycosylated hemoglobin belongs on the list of cardiovascular risk factors. Third, these studies highlight the importance of ongoing clinical trials of reducing glycosylated hemoglobin levels to reduce cardiovascular risk.

  • Clinical Trial Registration: A Statement from the International Committee of Medical Journal Editors

    • Catherine De Angelis,
    • Jeffrey M. Drazen,
    • Frank A. Frizelle,
    • Charlotte Haug,
    • John Hoey,
    • Richard Horton,
    • Sheldon Kotzin,
    • Christine Laine,
    • Ana Marusic,
    • A. John P.M. Overbeke,
    • Torben V. Schroeder,
    • Harold C. Sox,
    • and Martin B. Van Der Weyden
    Ann Intern Med September 21, 2004 141:477-478

    In this editorial, published simultaneously in all member journals, the International Committee of Medical Journal Editors (ICMJE) proposes comprehensive trials registration as a solution to the problem of selective awareness of clinical trials. The Committee announces that all 11 ICMJE member journals will adopt a trials-registration policy that promotes this goal.

On Being a Doctor

  • Foreign Body of the Heart

    • Lawrence Zaroff
    Ann Intern Med September 21, 2004 141:479-480

    For doctors practicing for 20 to 30 years, the chance of avoiding a malpractice suit is equivalent to a tadpole growing wings and becoming a monarch. For 29 years, I kept up with my changing specialty, asked for appropriate consultations, and was available when called, but a foreign body of the heart turned me into your average frog.

Letters

  • “Wait-and-See”: An Alternative Approach to Managing Acute Hepatitis C with High-Dose Interferon-α Monotherapy

    • Neville R. Pimstone,
    • Daniel Pimstone,
    • Theparat Saicheur,
    • Jerry Powell,
    • and Andy S. Yu
    Ann Intern Med September 21, 2004 141:W-91-W-92

  • Future Research on Disclosure of Medical Errors

    • Jonathan R. Cohen
    Ann Intern Med September 21, 2004 141:481

  • d-Dimer and Venous Thromboembolism

    • Stephen J. Wolf
    Ann Intern Med September 21, 2004 141:481

  • d-Dimer and Venous Thromboembolism

    • Grégoire Le Gal,
    • Marc Righini,
    • and Henri Bounameaux
    Ann Intern Med September 21, 2004 141:481-482

  • d-Dimer and Venous Thromboembolism

    • John T. Philbrick,
    • Steven Heim,
    • and Joel M. Schectman
    Ann Intern Med September 21, 2004 141:482

  • d-Dimer and Venous Thromboembolism

    • Fabio Puglisi and
    • Edda Federico
    Ann Intern Med September 21, 2004 141:482-483

  • d-Dimer and Venous Thromboembolism

    • Russell D. Hull,
    • William A. Ghali,
    • Rollin F. Brant,
    • and Paul D. Stein
    Ann Intern Med September 21, 2004 141:483

  • Factor V Leiden and Venous Thromboembolism

    • Philip T. Murphy
    Ann Intern Med September 21, 2004 141:483-484

  • Factor V Leiden and Venous Thromboembolism

    • Jan P. Vandenbroucke and
    • Frits R. Rosendaal
    Ann Intern Med September 21, 2004 141:484

  • Factor V Leiden and Venous Thromboembolism

    • Klaus Juul,
    • Børge G. Nordestgaard,
    • and Anne Tybjærg-Hansen
    Ann Intern Med September 21, 2004 141:484-485

  • Excess Body Weight in Critically Ill Patients

    • Marcus J. Schultz and
    • Esther K. Wolthuis
    Ann Intern Med September 21, 2004 141:485

  • Excess Body Weight in Critically Ill Patients

    • James M. O'Brien, Jr and
    • Carolyn H. Welsh
    Ann Intern Med September 21, 2004 141:485-486

  • Update in Perioperative Medicine

    • Paul Casner
    Ann Intern Med September 21, 2004 141:486

  • Update in Perioperative Medicine

    • Stephen A. Hilty
    Ann Intern Med September 21, 2004 141:486

  • Update in Perioperative Medicine

    • Gerald W. Smetana,
    • Steven L. Cohn,
    • and Valerie A. Lawrence
    Ann Intern Med September 21, 2004 141:486-487

  • Occupational Exposure to Bloodborne Pathogens

    • Michael L. Landrum,
    • Robert J. O'Connell,
    • and Gregory A. Deye
    Ann Intern Med September 21, 2004 141:487

Medical Writings: Book Notes

  • Presenting in Biomedicine: 500 Tips for Success

    • Sarah Garrison
    Ann Intern Med September 21, 2004 141:488

  • Music from Apartment 8: New and Selected Poems

    • Jason Karlawish
    Ann Intern Med September 21, 2004 141:488

Current Clinical Issues

  • Frailty—and Its Dangerous Effects—Might Be Preventable

    • Jennifer Fisher Wilson
    Ann Intern Med September 21, 2004 141:489-492

Medical Notices

  • Medical Notices

    Ann Intern Med September 21, 2004 141:0

Summaries for Patients

  • The Relationship Between Blood Sugar Levels and Cardiovascular Disease

    Ann Intern Med September 21, 2004 141:I-12

  • The Relationship between Blood Sugar Control and Cardiovascular Disease in Patients with Diabetes

    Ann Intern Med September 21, 2004 141:I-21

  • Manipulative Therapy for Patients with Shoulder Pain

    Ann Intern Med September 21, 2004 141:I-27

  • How Well Do Clinical and Lung Tissue Criteria for the Acute Respiratory Distress Syndrome Match?

    Ann Intern Med September 21, 2004 141:I-42

  • Improvements in 1-Year Outcomes before and after a Discharge Medication Program for Patients Hospitalized with Heart Disease

    Ann Intern Med September 21, 2004 141:I-43
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This Issue

September 21, 2004; 141 (6)
  1. Articles
  2. Improving Patient Care
  3. Updates
  4. Review
  5. Perspectives
  6. Editorials
  7. On Being a Doctor
  8. Letters
  9. Medical Writings: Book Notes
  10. Current Clinical Issues
  11. Medical Notices
  12. Summaries for Patients

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