Table of Contents

July 20, 2004; 141 (2)

Articles

  • Benefits and Harms of Doxycycline Treatment for Gulf War Veterans' Illnesses: A Randomized, Double-Blind, Placebo-Controlled Trial

    • Sam T. Donta,
    • Charles C. Engel, Jr.,
    • Joseph F. Collins,
    • Joel B. Baseman,
    • Lisa L. Dever,
    • Thomas Taylor,
    • Kathy D. Boardman,
    • Lewis E. Kazis,
    • Suzanne E. Martin,
    • Rebecca A. Horney,
    • Annette L. Wiseman,
    • Douglas S. Kernodle,
    • Raymond P. Smith,
    • Aldona L. Baltch,
    • Christine Handanos,
    • Brian Catto,
    • Luis Montalvo,
    • Michael Everson,
    • Warren Blackburn,
    • Manisha Thakore,
    • Sheldon T. Brown,
    • Larry Lutwick,
    • Dorothy Norwood,
    • Jack Bernstein,
    • Catherine Bacheller,
    • Bruce Ribner,
    • L. W. Preston Church,
    • Kenneth H. Wilson,
    • Prabhakar Guduru,
    • Robert Cooper,
    • Joseph Lentino,
    • Richard J. Hamill,
    • Arnold B. Gorin,
    • Victor Gordan,
    • David Wagner,
    • Cliff Robinson,
    • Pierre DeJace,
    • Ronald Greenfield,
    • Lisa Beck,
    • Marvin Bittner,
    • H. Ralph Schumacher,
    • Fredric Silverblatt,
    • James Schmitt,
    • Edward Wong,
    • Margaret A.K. Ryan,
    • Javier Figueroa,
    • Christopher Nice,
    • John R. Feussner,
    • and the VA Cooperative #475 Group
    Ann Intern Med July 20, 2004 141:85-94

    Researchers have hypothesized that certain Mycoplasma species may cause Gulf War veterans' illnesses (chronic diseases characterized by pain, fatigue, and cognitive symptoms) and that affected patients may benefit from doxycycline treatment. This study found that long-term treatment with doxycycline did not improve outcomes of these illnesses at 1 year.

  • The Incidence of End-Stage Renal Disease Is Increasing Faster than the Prevalence of Chronic Renal Insufficiency

    • Chi-yuan Hsu,
    • Eric Vittinghoff,
    • Feng Lin,
    • and Michael G. Shlipak
    Ann Intern Med July 20, 2004 141:95-101

    Growth in incident end-stage renal disease (ESRD) outpaced growth in prevalent chronic renal insufficiency, demonstrating that the ESRD epidemic in the United States is not merely due to more cases of kidney disease. Other potential contributors to ESRD growth are improved survival from nonrenal diseases and more liberal entry criteria for treatment programs.

  • Mortality Rates in Elderly Patients Who Take Different Angiotensin-Converting Enzyme Inhibitors after Acute Myocardial Infarction: A Class Effect?

    • Louise Pilote,
    • Michal Abrahamowicz,
    • Eric Rodrigues,
    • Mark J. Eisenberg,
    • and Elham Rahme
    Ann Intern Med July 20, 2004 141:102-112

    Survival benefits in the first year after acute myocardial infarction in patients 65 years of age or older seem to differ according to the specific angiotensin-converting enzyme inhibitor prescribed. Ramipril was associated with lower mortality than most other drugs in this class.

  • Brief Communication: The Relationship between Having a Living Will and Dying in Place

    • Howard B. Degenholtz,
    • YongJoo Rhee,
    • and Robert M. Arnold
    Ann Intern Med July 20, 2004 141:113-117

    Living wills are associated with dying in a patient's residence rather than in a hospital. During advance care planning, physicians should discuss patients' preferences for location of death.

Improving Patient Care

  • A Three-Part Intervention To Change the Use of Hormone Replacement Therapy in Response to New Evidence

    • Christianne L. Roumie,
    • Eric L. Grogan,
    • William Falbe,
    • Joseph Awad,
    • Theodore Speroff,
    • Robert S. Dittus,
    • and Tom A. Elasy
    Ann Intern Med July 20, 2004 141:118-125

    A multicomponent intervention (patient notification, provider education, electronic alerts in patient chart) seemed to increase the rate of stopping hormone replacement therapy after the release of results from the Women's Health Initiative study in July 2002.

Academia and Clinic

  • Allergic to Generics

    • Troyen A. Brennan and
    • Thomas H. Lee
    Ann Intern Med July 20, 2004 141:126-130

    The authors describe a patient who believes she is allergic to generic medications and a physician who refuses to prescribe brand-name drugs when generic alternatives are available. They discuss the ethical dilemmas of the patient's physician, who must weigh the interests of a patient who clings to beliefs that the physician thinks are unfounded against the interests of a just rationing program and the broader population it serves.

  • Ethics in Practice: Managed Care and the Changing Health Care Environment: Medicine as a Profession Managed Care Ethics Working Group Statement

    • Gail J. Povar,
    • Helen Blumen,
    • John Daniel,
    • Suzanne Daub,
    • Lois Evans,
    • Richard P. Holm,
    • Natalie Levkovich,
    • Alice O. McCarter,
    • James Sabin,
    • Lois Snyder,
    • Daniel Sulmasy,
    • Peter Vaughan,
    • Laurence D. Wellikson,
    • Amy Campbell,
    • and the Medicine as a Profession Managed Care Ethics Working Group*
    Ann Intern Med July 20, 2004 141:131-136

    This statement offers guidance on preserving the patient–physician relationship; patient rights and responsibilities; confidentiality and privacy; resource allocation and stewardship; the obligation of health plans to foster an ethical environment for the delivery of care; and the physician's responsibility to individual patients, the community, and the public health.

Reviews

  • Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease

    • Yiqing Song,
    • Meir J. Stampfer,
    • and Simin Liu
    Ann Intern Med July 20, 2004 141:137-147

    Previous studies on apolipoprotein E (apoE) ε4 allele as a risk factor for coronary heart disease have had conflicting results. This meta-analysis found that the apoE ε4 allele is strongly implicated as a risk factor for coronary heart disease.

  • Evaluation and Management of the Cardiovascular Patient Embarking on Air Travel

    • Stephen E. Possick and
    • Michèle Barry
    Ann Intern Med July 20, 2004 141:148-154

    In the context of a case presentation, the authors review the data on safe air travel after myocardial infarction and common complications of air travel after coronary artery revascularization; provide recommendations on safe air travel after myocardial infarction; discuss the safety of preflight screening and the in-flight environment for patients with pacemakers and implantable automatic defibrillators; and provide recommendations to prevent in-flight deep venous thrombosis.

Editorials

  • The Long Aftermath of the 1991 Gulf War

    • Simon Wessely
    Ann Intern Med July 20, 2004 141:155-156

    In this issue, Donta and colleagues report that doxycycline treatment has no effect on the health of symptomatic Gulf War veterans and that serologic evidence of Mycoplasma infection was unrelated to health. In the future, we cannot recommend long-term treatment with doxycycline or similar compounds for symptomatic veterans. It would, however, be naive to expect that this negative trial will be the end of the matter.

  • Is Improved Survival a Class Effect of Angiotensin-Converting Enzyme Inhibitors?

    • Sean Hennessy and
    • Stephen E. Kimmel
    Ann Intern Med July 20, 2004 141:157-158

    Pilote and colleagues' study in this issue indicates that in the absence of head-to-head randomized trials that test survival benefits of different angiotensin-converting enzyme inhibitors, the current level of scientific evidence is not sufficient to justify the selection of one proven drug in this class over another.

  • Advance Directives: Time To Move On

    • Joan M. Teno
    Ann Intern Med July 20, 2004 141:159-160

    In principle, increasing the use of advance directives is important. However, they are not sufficient to address the important concerns of family members of dying patients. We must move from a focus on single interventions, such as the living will, to public policies that use multifaceted interventions to provide competent, coordinated, and compassionate end-of-life care.

Letters

  • Pathogenesis of Hypertension

    • Paul G. Jenkins
    Ann Intern Med July 20, 2004 141:W-25

  • Late Sequelae of Induced Abortion

    • Nathan Hoeldtke
    Ann Intern Med July 20, 2004 141:161

  • Late Sequelae of Induced Abortion

    • William J. Stone
    Ann Intern Med July 20, 2004 141:161

  • Late Sequelae of Induced Abortion

    • David A. Grimes and
    • Mitchell D. Creinin
    Ann Intern Med July 20, 2004 141:161-162

  • Costs of False-Positive Cultures from Central Catheters

    • Todd Barton,
    • Mari Mizuta,
    • and Neil Fishman
    Ann Intern Med July 20, 2004 141:162

  • An “Inexcusable” Case of Muscle Rigidity and Shortness of Breath

    • Stuart Smalheiser and
    • Deborah A. Levine
    Ann Intern Med July 20, 2004 141:162-163

  • Correction: Successful Treatment of Refractory Sarcoidosis-Associated Uveitis with Infliximab

    Ann Intern Med July 20, 2004 141:163

Medical Writings: Book Notes

  • Breast Health and Common Breast Problems: A Practical Approach

    • Marilyn Terranella
    Ann Intern Med July 20, 2004 141:164

  • The Anatomy of Hope—How People Prevail in the Face of Illness

    • Kate Scannell
    Ann Intern Med July 20, 2004 141:164

Current Clinical Issues

  • Angiogenesis Therapy Moves beyond Cancer

    • Jennifer Fisher Wilson
    Ann Intern Med July 20, 2004 141:165-168

Book Listings

  • Book Listings

    Ann Intern Med July 20, 2004 141:0

Medical Notices

  • Medical Notices

    Ann Intern Med July 20, 2004 141:0

Summaries for Patients

  • Can Antibiotics Cure Gulf War Veterans' Illnesses?

    Ann Intern Med July 20, 2004 141:I-12

  • Possible Causes of the Increasing Incidence of End-Stage Renal Disease

    Ann Intern Med July 20, 2004 141:I-33

  • ACE Inhibitors after Heart Attacks: Varying Effects?

    Ann Intern Med July 20, 2004 141:I-34

  • Do Living Wills Affect the Setting Where People Die in the United States?

    Ann Intern Med July 20, 2004 141:I-40

  • Reducing the Prescription of Hormone Replacement Therapy after the Release of Study Results

    Ann Intern Med July 20, 2004 141:I-47
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This Issue

July 20, 2004; 141 (2)
  1. Articles
  2. Improving Patient Care
  3. Academia and Clinic
  4. Reviews
  5. Editorials
  6. Letters
  7. Medical Writings: Book Notes
  8. Current Clinical Issues
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients

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