Meta-Analysis: The Effect of Steroids on Survival and Shock during Sepsis Depends on the Dose

Figure 3. The relationship between the dose of steroids administered in the first 24 hours after enrollment in a sepsis trial and relative survival benefit ( ) is presented. There is a linear relationship (that is, the relative survival benefit decreases with high-dose steroids but increases with lower doses) (  = 0.02). One study ( ) was overly influential in our regression analysis, was a statistical outlier (  = 0.001) compared with the other trials, and was therefore excluded . This study was performed a decade before all of the other trials, included children, and had a high percentage of patients with meningitis.
Figure 3. The relationship between the dose of steroids administered in the first 24 hours after enrollment in a sepsis trial and relative survival benefit ( ) is presented. There is a linear relationship (that is, the relative survival benefit decreases with high-dose steroids but increases with lower doses) (  = 0.02). One study ( ) was overly influential in our regression analysis, was a statistical outlier (  = 0.001) compared with the other trials, and was therefore excluded . This study was performed a decade before all of the other trials, included children, and had a high percentage of patients with meningitis. Effects of steroid dose on survival.black circlesPwhite circleP(35)

This Article

  1. Ann Intern Med July 6, 2004 vol. 141 no. 1 47-56
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