Table of Contents

April 20, 2004; 140 (8)

Articles

  • d-Dimer for the Exclusion of Acute Venous Thrombosis and Pulmonary Embolism: A Systematic Review

    • Paul D. Stein,
    • Russell D. Hull,
    • Kalpesh C. Patel,
    • Ronald E. Olson,
    • William A. Ghali,
    • Rollin Brant,
    • Rita K. Biel,
    • Vinay Bharadia,
    • and Neeraj K. Kalra
    Ann Intern Med April 20, 2004 140:589-602

    Excluding a diagnosis from consideration requires a test result that will reduce its probability to below a threshold. Among tests for d-dimer, enzyme-linked immunosorbent assays (ELISAs) had the highest sensitivity and lowest negative likelihood ratio, which makes ELISA the best d-dimer test for excluding deep venous thrombosis and pulmonary embolism.

  • Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies

    • Eunyoung Cho,
    • Stephanie A. Smith-Warner,
    • John Ritz,
    • Piet A. van den Brandt,
    • Graham A. Colditz,
    • Aaron R. Folsom,
    • Jo L. Freudenheim,
    • Edward Giovannucci,
    • R. Alexandra Goldbohm,
    • Saxon Graham,
    • Lars Holmberg,
    • Dong-Hyun Kim,
    • Nea Malila,
    • Anthony B. Miller,
    • Pirjo Pietinen,
    • Thomas E. Rohan,
    • Thomas A. Sellers,
    • Frank E. Speizer,
    • Walter C. Willett,
    • Alicja Wolk,
    • and David J. Hunter
    Ann Intern Med April 20, 2004 140:603-613

    Alcohol intake, measured at one point in time, is associated with a modest relative elevation in colorectal cancer rate. This effect occurs mainly at the highest levels of alcohol intake.

  • The Spectrum of Severe Acute Respiratory Syndrome–Associated Coronavirus Infection

    • Timothy H. Rainer,
    • Paul K.S. Chan,
    • Margaret Ip,
    • Nelson Lee,
    • David S. Hui,
    • DeVilliers Smit,
    • Alan Wu,
    • Anil T. Ahuja,
    • John S. Tam,
    • Joseph J.Y. Sung,
    • and Peter Cameron
    Ann Intern Med April 20, 2004 140:614-619

    During an outbreak in Hong Kong, the authors searched for subclinical or mild forms of severe acute respiratory syndrome (SARS) coronavirus infection. They found no evidence for widespread occurrence of a mild form of SARS that would escape detection when patients present for clinical evaluation.

Reviews

  • Induced Abortion: An Overview for Internists

    • David A. Grimes and
    • Mitchell D. Creinin
    Ann Intern Med April 20, 2004 140:620-626

    Focusing on early induced abortions, the authors describe the numbers and characteristics of women having abortions, review the methods used, summarize safety data, explain how internists can respond to patients' requests for referral to abortion providers, and describe costs.

  • Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

    • Dennis J. Selkoe
    Ann Intern Med April 20, 2004 140:627-638

    In the last several years, Alzheimer disease researchers have come to agree that certain biochemical changes in the hippocampus and association cortices occur many years or decades before clinical symptoms. We can now describe a rough outline of the cascade of events leading to disease.

Perspectives

  • Health Care System Chaos Should Spur Innovation: Summary of a Report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine

    • Eric B. Larson and
    • the Society of General Internal Medicine (SGIM) Task Force on the Domain of General Internal Medicine*
    Ann Intern Med April 20, 2004 140:639-643

    Today's chaotic health care scene gives general internal medicine an opportunity to innovate and move beyond its current state of confusion. The field must adapt to a new world of consumerism, rising public expectations, widespread information dissemination, and pressures to hold down costs at a time when the demand for services is increasing because more people are surviving to live with chronic disease in old age.

Clinical Guidelines

  • Lipid Control in the Management of Type 2 Diabetes Mellitus: A Clinical Practice Guideline from the American College of Physicians

    • Vincenza Snow,
    • Mark D. Aronson,
    • E. Rodney Hornbake,
    • Christel Mottur-Pilson,
    • Kevin B. Weiss,
    • and the Clinical Efficacy Assessment Subcommittee of the American College of Physicians*
    Ann Intern Med April 20, 2004 140:644-649

    The American College of Physicians makes 4 recommendations for lipid control in patients with type 2 diabetes: 1) Use lipid-lowering therapy for secondary prevention of cardiovascular mortality and morbidity for all patients with known coronary artery disease and type 2 diabetes; 2) use a statin for primary prevention of macrovascular complications in patients with type 2 diabetes and other cardiovascular risk factors; 3) patients with type 2 diabetes who take statins should take at least moderate doses; 4) for patients with type 2 diabetes who are taking statins, routine monitoring of liver function tests or muscle enzymes is unnecessary except in specific circumstances.

  • Pharmacologic Lipid-Lowering Therapy in Type 2 Diabetes Mellitus: Background Paper for the American College of Physicians

    • Sandeep Vijan and
    • Rodney A. Hayward
    Ann Intern Med April 20, 2004 140:650-658

    In patients with type 2 diabetes, treatment with lipid-lowering agents reduces the risk for cardiovascular disease. Statins reduce cardiovascular disease risk in most patients, including those whose baseline low-density lipoprotein cholesterol levels are below 2.97 mmol/L (<115 mg/dL), and possibly below 2.59 mmol/L (<100 mg/dL). Most patients with diabetes should receive at least moderate doses of these drugs.

Editorials

  • Starting a Conversation about the Future of Internal Medicine

    • The Editors
    Ann Intern Med April 20, 2004 140:659

    We hope that the report by the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine in this issue will spur conversations among internists and their colleagues, patients, and others with a vested interest in seeing health care safely through dangerous waters. To start those conversations, we have asked 5 individuals to respond to different aspects of the report.

  • Generalism as Intention

    • Richard J. Baron
    Ann Intern Med April 20, 2004 140:659-660

    I agree with the thrust of the Society of General Internal Medicine Task Force report, but it left out an essential feature of daily practice: We connect, interpret, personalize, and customize medical care.

  • Working Together—That's Innovation!

    • Howard K. Rabinowitz
    Ann Intern Med April 20, 2004 140:660-661

    The combined force of all generalists who care for adults (internists and family physicians) could collectively speak with a much more powerful voice to address the critical issues about the important role of primary care in the health care system.

  • Making It Possible for General Internal Medicine To Survive

    • Robert B. Copeland
    Ann Intern Med April 20, 2004 140:661-662

    The Society of General Internal Medicine Task Force on the Domain of General Internal Medicine has reaffirmed that breadth and depth is the fundamental strength of internal medicine.

  • Reforming Payment for Primary Care: Making It Happen

    • Gail R. Wilensky
    Ann Intern Med April 20, 2004 140:662-663

    The Task Force's proposals for payment reform will fall on deaf ears if they increase the total costs of care. Evidence to the contrary is essential.

  • Customizing Residency Education

    • Holly J. Humphrey
    Ann Intern Med April 20, 2004 140:663-664

    The Task Force recommends using residency training to prepare for the requirements of a specific practice: subspecialist or generalist, rural or urban, and predominantly outpatient or inpatient setting. I concur, but with reservations.

Letters

  • Potentially Fatal Interaction between Diltiazem and Statins

    • Patrick Gladding,
    • Helen Pilmore,
    • and Colin Edwards
    Ann Intern Med April 20, 2004 140:W-31

  • Another Presentation of Gout

    • Mohamed El Sandid and
    • Ha Ta
    Ann Intern Med April 20, 2004 140:W-32

  • Mucinous Appendiceal Adenocarcinoma Presenting 5 Years after Appendectomy

    • Michael A. Thompson,
    • Rendell W. Ashton,
    • and Henry C. Pitot
    Ann Intern Med April 20, 2004 140:W-33

  • Retrobulbar Optic Neuritis Associated with Infliximab in a Patient with Crohn Disease

    • Betsy Y.C. Strong,
    • Barbara C. Erny,
    • Howard Herzenberg,
    • and Kristen J. Razzeca
    Ann Intern Med April 20, 2004 140:W-34

  • Spinal Manipulation for Low Back Pain

    • John D. Childs and
    • Timothy W. Flynn
    Ann Intern Med April 20, 2004 140:665

  • Spinal Manipulation for Low Back Pain

    • Carl M. Shapiro
    Ann Intern Med April 20, 2004 140:665

  • Spinal Manipulation for Low Back Pain

    • Paul G. Shekelle,
    • Sally C. Morton,
    • and Willem J.J. Assendelft
    Ann Intern Med April 20, 2004 140:665-666

  • Insulin Combination Therapy in Type 2 Diabetes Mellitus

    • Yusuf Hassan,
    • Gaurav Gupta,
    • and Saira Hassan
    Ann Intern Med April 20, 2004 140:666

  • Insulin Combination Therapy in Type 2 Diabetes Mellitus

    • Nasser Mikhail and
    • Soma Wali
    Ann Intern Med April 20, 2004 140:666-667

  • Insulin Combination Therapy in Type 2 Diabetes Mellitus

    • Andreas Fritsche,
    • Hans-Ulrich Häring,
    • and Matthias Axel Schweitzer
    Ann Intern Med April 20, 2004 140:667

  • Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus

    • Anil K. Mandal
    Ann Intern Med April 20, 2004 140:667-668

  • Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus

    • Kazuomi Kario and
    • Kazuyuki Shimada
    Ann Intern Med April 20, 2004 140:668

  • Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus

    • Adrienne A.M. Zandbergen,
    • Marinus G.A. Baggen,
    • and Rob J.Th. Ouwendijk
    Ann Intern Med April 20, 2004 140:668-669

  • Computer Physician Order Entry

    • David B. Edwards
    Ann Intern Med April 20, 2004 140:669

  • Computer Physician Order Entry

    • Barton M. Nassberg
    Ann Intern Med April 20, 2004 140:669

  • Computer Physician Order Entry

    • Gilad J. Kuperman and
    • Richard F. Gibson
    Ann Intern Med April 20, 2004 140:669-670

  • The Rise of Litigation in Human Subjects Research

    • Larry D. Scott
    Ann Intern Med April 20, 2004 140:670

  • The Rise of Litigation in Human Subjects Research

    • Harvey Murff
    Ann Intern Med April 20, 2004 140:670

  • Ezetimibe and Statin-Associated Myopathy

    • Richard Fux,
    • Klaus Mörike,
    • Udo-Frank Gundel,
    • Rüdiger Hartmann,
    • and Christoph H. Gleiter
    Ann Intern Med April 20, 2004 140:671-672

  • Remission of Hepatitis B Virus-Related Vasculitis with Lamivudine

    • Takuya Sawabe,
    • Takeshi Uenotsuchi,
    • Shinichi Imafuku,
    • Hiroshi Kohno,
    • Junichi Arima,
    • and Takahiko Horiuchi
    Ann Intern Med April 20, 2004 140:672-673

  • Whipple Pancarditis as a Cause of Heart Failure

    • Ram Y. Gordon,
    • Emily Blumberg,
    • Susan C. Brozena,
    • and Billie Fyfe
    Ann Intern Med April 20, 2004 140:673-674

  • Organizational Changes in a Single Intensive Care Unit Affect Benchmarking

    • Arthur R.H. van Zanten and
    • Kees H. Polderman
    Ann Intern Med April 20, 2004 140:674-675

Medical Writings: Book Notes

  • Applied Longitudinal Data Analysis for Epidemiology: A Practical Guide

    • Leonard E. Braitman
    Ann Intern Med April 20, 2004 140:676

  • Handbook of Clinical Nutrition and Aging

    • Nancy J. Stiles
    Ann Intern Med April 20, 2004 140:676

Current Clinical Issues

  • Cheaper Drugs in Foreign Markets Increase the Focus on Domestic Drug Prices

    • Jennifer Fisher Wilson
    Ann Intern Med April 20, 2004 140:677-680

Book Listings

  • Book Listings

    Ann Intern Med April 20, 2004 140:0

Medical Notices

  • Medical Notices

    Ann Intern Med April 20, 2004 140:0

Summaries for Patients

  • Ability of Different d-Dimer Tests To Exclude Deep Venous Thrombosis and Pulmonary Embolism

    Ann Intern Med April 20, 2004 140:I-42

  • Alcohol Consumption and the Risk for Colorectal Cancer

    Ann Intern Med April 20, 2004 140:I-55

  • Do Some Patients with SARS Have Mild Disease?

    Ann Intern Med April 20, 2004 140:I-65

  • Control of Lipids in Patients with Type 2 Diabetes: Recommendations from the American College of Physicians

    Ann Intern Med April 20, 2004 140:I-85
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This Issue

April 20, 2004; 140 (8)
  1. Articles
  2. Reviews
  3. Perspectives
  4. Clinical Guidelines
  5. Editorials
  6. Letters
  7. Medical Writings: Book Notes
  8. Current Clinical Issues
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients

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