Table of Contents

June 1, 2004; 140 (11)

Articles

  • Statin therapy can modulate early pathophysiologic processes in patients with acute coronary syndromes. In this observational study, patients taking statins before admission for acute coronary syndromes and patients who started taking statins after admission had better outcomes than patients who did not take statins.

  • Once-daily subcutaneous fondaparinux was at least as effective and safe as twice-daily, body weight–adjusted enoxaparin in the initial treatment of symptomatic deep venous thrombosis.

  • The authors studied direct observation of competence, a new approach to improving faculty skills in evaluating trainees' clinical ability. The new method appeared to make faculty more critical observers of trainee performance.

  • Childhood autoimmune diabetes is associated with autoimmunity that starts before 2 years of age. Autoimmunity that starts after 2 years is much less likely to lead to diabetes.

Improving Patient Care

  • This prospective, controlled study of almost 10 000 patients found that a quality improvement collaborative did not significantly affect the quality of care. We need additional research to improve methods of implementing quality improvement programs in order to achieve better results.

  • Many of the intensive efforts to improve health care quality and safety use the quality improvement collaborative method, an approach emphasizing collaborative learning and exchange of insights and support among a set of health care organizations. Unfortunately, the widespread use of this method is based not on solid evidence but on shared beliefs and anecdotal experience that may overstate its actual effectiveness.

Academia and Clinic

  • The Residency Review Committee for Internal Medicine of the Accreditation Council for Graduate Medical Education proposes a new outcomes-based accreditation strategy for residency training programs in internal medicine. It shifts residency program accreditation from external audit of educational process to continuous assessment and improvement of trainee clinical competence.

Review

  • Few surveillance systems have been specifically designed for collecting and analyzing data for the early detection of a bioterrorist event. Past studies of surveillance systems for detecting bioterrorism are insufficient to characterize the timeliness of detection or its sensitivity and specificity. As a result, they may compromise clinical and public health decision making.

Editorials

  • The current evidence leaves us uncertain about whether starting statin therapy at the time of admission for an acute coronary syndrome is more effective than starting this therapy later. While we wait for the results of large randomized trials, we can reflect on the many reasons for caution in drawing firm conclusions from observational studies of treatment effectiveness.

  • After almost 50 years without any substantial progress, antithrombotic treatment of patients with venous thromboembolism has finally evolved. Factor Xa or thrombin inhibitors will probably allow antithrombotic treatment that is effective, safe, and simple enough for all physicians to use in most outpatients.

  • Two papers in this issue indicate the dramatic and important movement of outcomes-based thinking into the world of medical education and training.

On Being a Doctor

  • Two patients, two doctor visits, two widely different experiences.

Letters

Medical Writings: Book Notes

Book Listings

Medical Notices

Supplement: Diabetes Translation and Public Health: 25 Years of CDC Research and Programs

Summaries for Patients