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In treatment-experienced patients with suboptimal viral suppression, tenofovir disoproxil fumarate significantly reduced HIV-1 RNA levels and had a safety profile similar to that of placebo.
For unvaccinated or high-risk vaccinated patients during the influenza season, treating with oseltamivir without previous testing is cost-effective. For other patients, rapid testing for influenza followed by treatment with oseltamivir is cost-effective. Empirical amantadine treatment is a low-cost alternative to oseltamivir.
Bone marrow edema on magnetic resonance imaging of the knee predicts subsequent deterioration of knee osteoarthritis. Bone marrow edema is associated with limb malalignment, which partially explains its relation to progressive knee damage.
Although the clinical features of inhalational anthrax overlap with those of common viral respiratory infections, some features are characteristic of anthrax. A triage algorithm based on these features may help to diagnose presumptive inhalational anthrax in the setting of a large-scale anthrax attack.
In patients with autoimmune thyroiditis, antibodies to all major thyroid antigens gradually disappear after complete ablation of thyroid tissue. This finding is evidence that production of autoantibody requires the continuing presence of autoantigen.
Recent discoveries about gene transcription have advanced our understanding of the molecular mechanisms of corticosteroid suppression of inflammation.
The authors review the evidence about the health status of internationally adopted children and describe how these children can transmit disease to members of their adoptive families. They conclude with advice for people who are about to travel abroad to bring an adopted child to his or her new home.
Hupert and colleagues address the problem of efficient, accurate triage of patients with suspected anthrax. In this commentary, I focus on the article's principal product: a triage algorithm for people who have symptoms of inhalational anthrax.
The articles contained in the supplement to this issue of Annals prompt three questions: What exactly do we mean by successful aging? How does this concept advance our ability to enhance the lives of older adults? What does it mean for clinical practice?
It turned out that Dr. Ernst, the medical resident who came to declare my father dead, had known him. I wondered how Dr. Ernst would go through the nonritual of declaring death with us watching, we medical experts, we intimates of my father's heart.
This Update reviews several important papers on Barrett esophagus,Helicobacter pylori, hepatology, and inflammatory bowel disease.
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