NIH Conferences

Pathogenesis and Treatment of HIV-Associated Renal Diseases: Lessons from Clinical and Animal Studies, Molecular Pathologic Correlations, and Genetic Investigations

Figure 2. . Interferon-α protein was assessed in microdissected renal glomerular and interstitial tissue from 6 patients with HIV-associated nephropathy, 4 patients with HIV-associated immune-mediated glomerulonephritis, 3 HIV-infected patients who died without autopsy evidence of renal disease, 9 patients with idiopathic focal segmental glomerulosclerosis in the absence of HIV infection, and renal tissue of uninfected patients without clinical or pathologic evidence of renal disease by high-performance immunoaffinity chromatography and chemiluminescent enzyme-linked immunosorbent assay. Renal interstitial and glomerular interferon-α protein levels were significantly higher in renal tissue from patients with HIV-associated nephropathy than in tissue from all other groups ( = 0.002; analysis of variance). A similar pattern was noted for nonpolymorphic major histocompatibility II locus and interferon-γ receptor protein levels. Error bars indicate SEs. * = 0.002. Interferon-α protein expression in renal tissue compartmentsPP