Table of Contents

July 15, 2003; 139 (2)

Articles

  • Alternation of Antiretroviral Drug Regimens for HIV Infection: A Randomized, Controlled Trial

    • Javier Martinez-Picado,
    • Eugènia Negredo,
    • Lidia Ruiz,
    • Ayumi Shintani,
    • Carmina R. Fumaz,
    • Carlos Zala,
    • Pere Domingo,
    • Josep Vilaró,
    • Josep M. Llibre,
    • Pompeyo Viciana,
    • Kurt Hertogs,
    • Charles Boucher,
    • Richard T. D'Aquila,
    • Bonaventura Clotet,
    • and the SWATCH Study Team*
    Ann Intern Med July 15, 2003 139:81-89

    This pilot study randomly assigned patients to receive one of two triple-drug regimens (stavudine, didanosine, and efavirenz or zidovudine, lamivudine, and nelfinavir) or to alternate between the two regimens every 3 months. Alternating the regimens delayed virologic failure.

  • Effect of Losartan on Microalbuminuria in Normotensive Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial

    • Adrienne A.M. Zandbergen,
    • Marinus G.A. Baggen,
    • Steven W.J. Lamberts,
    • Aart H. Bootsma,
    • Dick de Zeeuw,
    • and Rob J.Th. Ouwendijk
    Ann Intern Med July 15, 2003 139:90-96

    The angiotensin-receptor antagonist losartan reduces urinary albumin excretion in normotensive patients with type 2 diabetes and microalbuminuria. The effect of losartan on proteinuria is independent of its effect on blood pressure.

  • Statin Use, Clinical Fracture, and Bone Density in Postmenopausal Women: Results from the Women's Health Initiative Observational Study

    • Andrea Z. LaCroix,
    • Jane A. Cauley,
    • Mary Pettinger,
    • Judith Hsia,
    • Douglas C. Bauer,
    • Joan McGowan,
    • Zhao Chen,
    • Cora E. Lewis,
    • S. Gene McNeeley,
    • Maureen D. Passaro,
    • and Rebecca D. Jackson
    Ann Intern Med July 15, 2003 139:97-104

    Statin use did not reduce fracture risk or increase bone density in the Women's Health Initiative Observational Study. The accumulated evidence does not support using statins to prevent or treat osteoporosis.

  • Effects of an Angiotensin-Converting Enzyme Inhibitor on Residual Renal Function in Patients Receiving Peritoneal Dialysis: A Randomized, Controlled Study

    • Philip Kam-Tao Li,
    • Kai-Ming Chow,
    • Teresa Yuk-Hwa Wong,
    • Chi-Bon Leung,
    • and Cheuk-Chun Szeto
    Ann Intern Med July 15, 2003 139:105-112

    The angiotensin-converting enzyme inhibitor ramipril may reduce the rate of decline in residual renal function in patients who have end-stage renal failure and are undergoing peritoneal dialysis.

Academia and Clinic

  • Diagnosis and Management of Adults with Pharyngitis: A Cost-Effectiveness Analysis

    • Joan M. Neuner,
    • Mary Beth Hamel,
    • Russell S. Phillips,
    • Kira Bona,
    • and Mark D. Aronson
    Ann Intern Med July 15, 2003 139:113-122

    Observation, culture, and two rapid antigen test strategies for diagnosing and treating suspected group A β-hemolytic streptococcal (GAS) pharyngitis in adults have very similar cost-effectiveness. Culture is the least expensive and most effective strategy for pharyngitis when the probability of GAS is 10% or greater. Empirical antibiotic treatment is never the best strategy in adults, except possibly in patients with a very high probability of GAS.

Review

  • Management of Patients Undergoing Percutaneous Coronary Revascularization

    • Glenn N. Levine,
    • Morton J. Kern,
    • Peter B. Berger,
    • David L. Brown,
    • Lloyd W. Klein,
    • Dean J. Kereiakes,
    • Timothy A. Sanborn,
    • Alice K. Jacobs,
    • and for the American Heart Association Diagnostic and Interventional Catheterization Committee and Council on Clinical Cardiology
    Ann Intern Med July 15, 2003 139:123-136

    This review discusses the risks and complications of percutaneous coronary revascularization, as well as optimum patient management before, during, and after the procedure.

Clinical Guidelines

  • National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification

    • Andrew S. Levey,
    • Josef Coresh,
    • Ethan Balk,
    • Annamaria T. Kausz,
    • Adeera Levin,
    • Michael W. Steffes,
    • Ronald J. Hogg,
    • Ronald D. Perrone,
    • Joseph Lau,
    • and Garabed Eknoyan
    Ann Intern Med July 15, 2003 139:137-147

    This paper describes a classification system for chronic kidney disease and summarizes recommendations on early detection in adults. Key recommendations include identifying persons at increased risk, using the albumin–creatinine ratio in untimed urine specimens, and using prediction equations to estimate the glomerular filtration rate from the serum creatinine level.

Editorials

  • Is It Time To Proactively Switch Successful Antiretroviral Therapy? Carefully Check Your SWATCH

    • Michael Saag
    Ann Intern Med July 15, 2003 139:148-149

    In Martinez-Picado and colleagues' study reported in this issue, fewer virologic failures occurred with alternating antiretroviral regimens than with continuous treatment with one triple-drug regimen. However, several subtleties in the study design and the analysis raise questions about the meaning of the findings and their application to clinical practice.

  • Diagnosing Strep Throat in the Adult Patient: Do Clinical Criteria Really Suffice?

    • Alan L. Bisno
    Ann Intern Med July 15, 2003 139:150-151

    In this issue, Neuner and colleagues report a cost-effectiveness analysis of the diagnosis and treatment of adults with pharyngitis caused by group A β-hemolytic streptococcus. Contrary to a recent American College of Physicians practice guideline, they found that treatment based on history and physical findings alone was the least effective strategy. Until controlled clinical studies measure the added value of the rapid antigen test or culture for GAS, the author does not believe it is prudent to rely exclusively on clinical criteria to diagnose and manage pharyngitis.

Letters

  • Empathy and the Literary Imagination

    • Thomas S. Artim
    Ann Intern Med July 15, 2003 139:W-57

  • Torsades de Pointes Due to Methadone

    • David De Bels,
    • Michel Staroukine,
    • and Jacques Devriendt
    Ann Intern Med July 15, 2003 139:W-58

  • Sudden-Onset Thrombocytopenia with Oxaliplatin

    • Frederick G. Dold and
    • Edith P. Mitchell
    Ann Intern Med July 15, 2003 139:W-59

  • Complementary and Alternative Medicine in Cancer

    • Nina Moliver
    Ann Intern Med July 15, 2003 139:152

  • Complementary and Alternative Medicine in Cancer

    • Wendy A. Weiger,
    • Ted J. Kaptchuk,
    • and David M. Eisenberg
    Ann Intern Med July 15, 2003 139:152

  • Propensity Scores for Rare Outcomes and Common Treatments

    • W T. Longstreth, Jr,
    • Carol E. Fahrenbruch,
    • and Thomas D. Koepsell
    Ann Intern Med July 15, 2003 139:152-153

  • A Lesson in Poverty

    • Samiya Razvi and
    • Mohammad A. Rafey
    Ann Intern Med July 15, 2003 139:153

  • Herpes Simplex Virus–Associated Sepsis in a Previously Infected Immunocompetent Adult

    • George Zahariadis,
    • Keith R. Jerome,
    • and Lawrence Corey
    Ann Intern Med July 15, 2003 139:153-154

  • The Impact of Methadone Induction on Cardiac Conduction in Opiate Users

    • Bridget A. Martell,
    • Julia H. Arnsten,
    • Beevash Ray,
    • and Marc N. Gourevitch
    Ann Intern Med July 15, 2003 139:154-155

  • Correction: Advising Patients Who Seek Complementary and Alternative Medical Therapies for Cancer

    Ann Intern Med July 15, 2003 139:155

Medical Writings: Book Notes

  • Healthcare Informatics and Information Synthesis

    • Thomas R. Yackel
    Ann Intern Med July 15, 2003 139:156

  • Inflammatory Bowel Disease: Diagnosis and Therapeutics

    • Anthony J. DiMarino, Jr
    Ann Intern Med July 15, 2003 139:156

Current Clinical Issues

  • Building African AIDS Care from the Ground Up

    • Jennifer Fisher Wilson
    Ann Intern Med July 15, 2003 139:157-160

Book Listings

Medical Notices

Summaries for Patients

  • Alternating Drug Regimens To Treat HIV Infection

    Ann Intern Med July 15, 2003 139:I-16

  • The Blood Pressure Drug Losartan Appears To Benefit the Kidneys of People with Type 2 Diabetes Who Do Not Have High Blood Pressure

    Ann Intern Med July 15, 2003 139:I-24

  • Relationship between Use of Cholesterol-Lowering Drugs (Statins) and Osteoporosis in Women after Menopause

    Ann Intern Med July 15, 2003 139:I-27

  • Preventing Worsening Kidney Function in Patients Receiving Peritoneal Dialysis

    Ann Intern Med July 15, 2003 139:I-32

  • Management of Patients Undergoing Percutaneous Coronary Interventions

    Ann Intern Med July 15, 2003 139:I-34

  • Diagnosis and Evaluation of Patients with Chronic Kidney Disease: Recommendations from the National Kidney Foundation

    Ann Intern Med July 15, 2003 139:I-36
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This Issue

July 15, 2003; 139 (2)
  1. Articles
  2. Academia and Clinic
  3. Review
  4. Clinical Guidelines
  5. Editorials
  6. Letters
  7. Medical Writings: Book Notes
  8. Current Clinical Issues
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients

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