Defibrillators and Sudden Death

  1. Justin A. Ezekowitz, MBBCh;
  2. Finlay A. McAlister, MD; and
  3. Paul W. Armstrong, MD
  1. From University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

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    IN RESPONSE:

    We disagree with Dr. Cohn's assertion that MADIT II should not be incorporated into the clinical decision-making process and should thus have been excluded from our meta-analysis of implantable cardioverter defibrillators in patients at increased risk for sudden cardiac death. The presence of ventricular ectopic beats on a Holter monitor was initially an inclusion criterion for MADIT II. However, after 23 patients were recruited, the executive committee eliminated this criterion (1). Because those 23 patients represent less than 2% of the total enrolled sample in MADIT II, we believe their inclusion would only minimally influence interpretation of the trial's results.

    Justin A. Ezekowitz, MBBCh

    Finlay A. McAlister, MD

    Paul W. Armstrong, MD

    University of Alberta; Edmonton, Alberta T6G 2H7, Canada

    The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:

    •Include no more than 300 words of text, three authors, and five references

    •Type with double-spacing

    •Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.

    Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.

    Annals welcomes electronically submitted letters.

    Reference

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