Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules

Appendix (Figure 10). Test selection is shown to be a function of pretest probability and the corresponding post-test probability
once the results of CT are known. Positron emission tomography with 18-fluorodeoxyglucose ( ) is recommended over a wider
range of post-test probabilities when societal willingness to pay is $100 000 per quality-adjusted life-year ( ) gained. Note
that surgery is preferred when PET results are positive, biopsy is preferred when PET results are negative, and watchful waiting
is preferred when biopsy results are nondiagnostic.
Recommended sequence of diagnostic testing in patients who are at high risk for surgical complications, according to pretest
probability, computed tomography (CT) results, and threshold that determines cost-effectiveness.FDG-PETQALY
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Ann Intern Med
May 6, 2003
vol. 138
no. 9
724-735