Table of Contents

April 15, 2003; 138 (8)

Articles

  • Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees

    • Leena Sharma,
    • Dorothy D. Dunlop,
    • September Cahue,
    • Jing Song,
    • and Karen W. Hayes
    Ann Intern Med April 15, 2003 138:613-619

    Greater quadriceps strength at baseline was associated with increased likelihood of tibiofemoral osteoarthritis progression in malaligned knees and lax knees. This surprising observation will require us to reconsider our approach to developing muscle strength that protects the osteoarthritic knee.

  • Survival Benefit of Initiating Antiretroviral Therapy in HIV-Infected Persons in Different CD4+ Cell Strata

    • Frank J. Palella, Jr.,
    • Maria Deloria-Knoll,
    • Joan S. Chmiel,
    • Anne C. Moorman,
    • Kathleen C. Wood,
    • Alan E. Greenberg,
    • Scott D. Holmberg,
    • and the HIV Outpatient Study (HOPS) Investigators*
    Ann Intern Med April 15, 2003 138:620-626

    Among HIV-infected persons with CD4+ cell counts of 0.201 to 0.350 × 109 cells/L, initiating antiretroviral therapy is associated with lower mortality than if therapy is delayed until the CD4+ cell count decreases further. Initiation of antiretroviral therapy at CD4+ cell counts of 0.351 to 0.500 × 109 cells/L may help improve survival.

  • Serum Ferritin Level Predicts Advanced Hepatic Fibrosis among U.S. Patients with Phenotypic Hemochromatosis

    • Elizabeth D. Morrison,
    • David J. Brandhagen,
    • Pradyumna D. Phatak,
    • James C. Barton,
    • Edward L. Krawitt,
    • Hashem B. El-Serag,
    • Stuart C. Gordon,
    • Mark V. Galan,
    • Bruce Y. Tung,
    • George N. Ioannou,
    • and Kris V. Kowdley
    Ann Intern Med April 15, 2003 138:627-633

    Patients with hemochromatosis and serum ferritin levels less than 1000 µg/L are unlikely to have cirrhosis. Liver biopsy to screen for cirrhosis may be unnecessary in such patients, regardless of age or serum liver enzyme levels.

  • Pulmonary Vein Stenosis after Catheter Ablation of Atrial Fibrillation: Emergence of a New Clinical Syndrome

    • Eduardo B. Saad,
    • Nassir F. Marrouche,
    • Cynthia P. Saad,
    • Edward Ha,
    • Dianna Bash,
    • Richard D. White,
    • John Rhodes,
    • Lourdes Prieto,
    • David O. Martin,
    • Walid I. Saliba,
    • Robert A. Schweikert,
    • and Andrea Natale
    Ann Intern Med April 15, 2003 138:634-638

    Severe pulmonary vein stenosis after catheter ablation of atrial fibrillation is associated with respiratory symptoms that often mimic more common diseases.

Brief Communications

  • Chemotherapy Use among Medicare Beneficiaries at the End of Life

    • Ezekiel J. Emanuel,
    • Yinong Young-Xu,
    • Norman G. Levinsky,
    • Gail Gazelle,
    • Olga Saynina,
    • and Arlene S. Ash
    Ann Intern Med April 15, 2003 138:639-643

    Among patients who died of cancer, chemotherapy was used frequently in the last 3 months of life. Patients with cancer who are dying often receive chemotherapy for types of cancer that seldom respond to chemotherapy.

Academia and Clinic

  • Multivariable Analysis: A Primer for Readers of Medical Research

    • Mitchell H. Katz
    Ann Intern Med April 15, 2003 138:644-650

    This paper reviews the basics of multivariable analysis, including what multivariable models are, why they are used, what assumptions underlie them, how to interpret them, and how to evaluate them.

Updates

  • Update on Parkinson Disease

    • Andrew Siderowf and
    • Matthew Stern
    Ann Intern Med April 15, 2003 138:651-658

    This Update reports new research on genetic and environmental factors in the etiology of Parkinson disease and emerging data on treatment. This research has moved the field closer to understanding the mechanisms of cell death in Parkinson disease well enough to design rational therapies.

Review

  • Malignant Glioma Physiology: Cellular Response to Hypoxia and Its Role in Tumor Progression

    • Daniel J. Brat and
    • Timothy B. Mapstone
    Ann Intern Med April 15, 2003 138:659-668

    Malignant gliomas have invasive properties that make them nearly impossible to cure surgically. Most physicians agree that the best hope for long-term control lies with adjunctive therapies. One emerging field of research attempts to limit tumor growth by interfering with vascular proliferation that occurs as a physiologic response to hypoxia within the tumor.

Perspectives

  • Clinical Research and the Physician–Patient Relationship

    • Donna T. Chen,
    • Franklin G. Miller,
    • and Donald L. Rosenstein
    Ann Intern Med April 15, 2003 138:669-672

    The authors discuss several ethical and practical challenges facing physicians who wish to help their patients decide about volunteering for clinical trials. They assert that medical education should prepare physicians to inform patients about participation in clinical research.

History of Medicine

  • The Symbol of Modern Medicine: Why One Snake Is More Than Two*

    • Robert A. Wilcox and
    • Emma M. Whitham
    Ann Intern Med April 15, 2003 138:673-677

    This paper describes the ancient origin of the Asklepian (the single serpent–entwined staff of Asklepios, the ancient Greco-Roman god of medicine) and how a misunderstanding of ancient mythology and iconography led to popular acceptance of the modern caduceus as a medical symbol.

Editorials

  • Is a Strong Quadriceps Muscle Bad for a Patient with Knee Osteoarthritis?

    • Kenneth D. Brandt
    Ann Intern Med April 15, 2003 138:678-679

    Sharma and colleagues' interesting results in this issue are hypothesis generating rather than conclusive evidence that standard quadriceps-strengthening exercise programs harm patients with osteoarthritis who have greater quadriceps strength. It is too early to begin tailoring strength-maintenance programs to particular subsets of patients.

  • When To Start Therapy for HIV Infection: A Swinging Pendulum in Search of Data

    • H. Clifford Lane and
    • James D. Neaton
    Ann Intern Med April 15, 2003 138:680-681

    The fundamental unanswered questions about the treatment of patients with HIV infection include when to start therapy, what therapy to start, and when to change therapy. The study by Palella and colleagues in this issue supports earlier rather than later intervention. Although their data are unlikely to change current recommendations about when to initiate therapy, they generate new uncertainty that may lead to clinical trials that will contribute to this important debate.

  • Physiology in Medicine: A New Series in Annals of Internal Medicine

    • Harold C. Sox,
    • Dennis Ausiello,
    • Dale Benos,
    • and Paul Epstein
    Ann Intern Med April 15, 2003 138:682

    With the review by Brat and Mapstone in this issue, Annals begins a series of articles intended to help clinicians understand the scientific basis of new developments in diagnosis and treatment of disease. We will publish these articles under a distinguished name: Physiology in Medicine.

On Being a Doctor

  • Night and Day

    • Eric J. Warm
    Ann Intern Med April 15, 2003 138:683-684

    All was quiet. There was a dead man on the floor in Room 465, and I wasn't moving. On the first day of residency I would have been in his room, grabbing his shoulder, yelling, “Sir, are you okay?” On the first day of residency I would have pounded on his chest and asked questions later. On the first day of residency I would have broken ribs. But not this night.

Letters

  • Hepatotoxicity Associated with a Dietary Supplement

    • Brennan A. Scott,
    • Christoph Troppmann,
    • and Lorenzo Rossaro
    Ann Intern Med April 15, 2003 138:W-49

  • Effects of Three Therapies for Neck Pain

    • Oliver Kwan and
    • Jon Friel
    Ann Intern Med April 15, 2003 138:685

  • Effects of Three Therapies for Neck Pain

    • Jan Lucas Hoving,
    • Bart W. Koes,
    • and Henrica C.W. de Vet
    Ann Intern Med April 15, 2003 138:685-686

  • Subgroup Variation in Diagnostic Test Evaluation

    • Arthur T. Evans
    Ann Intern Med April 15, 2003 138:686

  • Subgroup Variation in Diagnostic Test Evaluation

    • Ronald R. Scobbo
    Ann Intern Med April 15, 2003 138:686

  • Subgroup Variation in Diagnostic Test Evaluation

    • Stephanie A. Mulherin and
    • William C. Miller
    Ann Intern Med April 15, 2003 138:686-687

  • Postmenopausal Hormone Replacement Therapy

    • Steven J. Meyerson
    Ann Intern Med April 15, 2003 138:687

  • Postmenopausal Hormone Replacement Therapy

    • Arthur B. Chausmer
    Ann Intern Med April 15, 2003 138:687-688

  • Postmenopausal Hormone Replacement Therapy

    • Francine Grodstein,
    • JoAnn E. Manson,
    • and Meir J. Stampfer
    Ann Intern Med April 15, 2003 138:688

  • Postmenopausal Hormone Replacement Therapy

    • Linda L. Humphrey,
    • Benjamin K.S. Chan,
    • and Harold C. Sox
    Ann Intern Med April 15, 2003 138:688-689

  • Screening for Postmenopausal Osteoporosis

    • Harry W. Daniell
    Ann Intern Med April 15, 2003 138:689

  • Screening for Postmenopausal Osteoporosis

    • Heidi D. Nelson
    Ann Intern Med April 15, 2003 138:689-690

  • Breast Cancer Screening

    • Daniel B. Kopans
    Ann Intern Med April 15, 2003 138:690

  • Breast Cancer Screening

    • Harold C. Sox
    Ann Intern Med April 15, 2003 138:690

  • Physicians and Patient Spirituality

    • Fritz Baumgartner
    Ann Intern Med April 15, 2003 138:690-691

  • Physicians and Patient Spirituality

    • John Graner
    Ann Intern Med April 15, 2003 138:691

  • Hepatitis B Virus Reactivation after a Single Session of Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

    • Giovan B. Vizzini,
    • Angelo Luca,
    • and Ignazio R. Marino
    Ann Intern Med April 15, 2003 138:691-692

  • Correction: Reversal of Warfarin–Induced Excessive Anticoagulation

    Ann Intern Med April 15, 2003 138:692

Current Clinical Issues

Book Listings

Medical Notices

Summaries for Patients

  • Upper Leg Muscle Strength and Osteoarthritis

    Ann Intern Med April 15, 2003 138:I-17

  • Immediate versus Delayed Treatment for HIV Infection

    Ann Intern Med April 15, 2003 138:I-28

  • Low Serum Ferritin Level Rules Out Advanced Liver Disease in Hemochromatosis

    Ann Intern Med April 15, 2003 138:I-30

  • Radiofrequency Treatment of Abnormal Heart Rhythm Can Damage the Vessels That Return Blood from the Lungs to the Heart

    Ann Intern Med April 15, 2003 138:I-41

  • Chemotherapy Use in the Last 6 Months of Life among Medicare Patients with Cancer

    Ann Intern Med April 15, 2003 138:I-44
« Previous | Next Issue »

This Issue

April 15, 2003; 138 (8)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Updates
  5. Review
  6. Perspectives
  7. History of Medicine
  8. Editorials
  9. On Being a Doctor
  10. Letters
  11. Current Clinical Issues
  12. Book Listings
  13. Medical Notices
  14. Summaries for Patients

Search in this issue:

Current Issue

  1. November 3, 2009, 151 (9)
  1. Alert me to current issues