Gene Vaccines[dhelix]

Figure 3. Studies in bone marrow chimeric mice demonstrated that after immunization with plasmid DNA encoding an antigen, cytolytic T lymphocytes were activated by antigen-presenting cells ( ) that either had been directly transfected by the DNA or had received antigen via cross-priming, in which a non–antigen-presenting cell initially produces the protein encoded by the DNA vaccine, then transfers the antigen in some form to a professional antigen-presenting cell for generation of MHC class I restricted cytolytic T cells. Production of the protein antigen in non–antigen-presenting cells, such as myocytes, cannot result in direct stimulation of cytolytic T cells .
Figure 3. Studies in bone marrow chimeric mice demonstrated that after immunization with plasmid DNA encoding an antigen, cytolytic T lymphocytes were activated by antigen-presenting cells ( ) that either had been directly transfected by the DNA or had received antigen via cross-priming, in which a non–antigen-presenting cell initially produces the protein encoded by the DNA vaccine, then transfers the antigen in some form to a professional antigen-presenting cell for generation of MHC class I restricted cytolytic T cells. Production of the protein antigen in non–antigen-presenting cells, such as myocytes, cannot result in direct stimulation of cytolytic T cells . Mechanism of antigen presentation for generation of cytolytic T cells after DNA vaccination.APC(3)

This Article

  1. Ann Intern Med April 1, 2003 vol. 138 no. 7 550-559
  1. AbstractFREE
  2. Figures
  3. Full Text
  4. Full Text (PDF)

Current Issue

  1. November 17, 2009, 151 (10)
  1. Alert me to current issues