Gene Vaccines[dhelix]

Figure 2. . Survival rates among mice immunized against influenza by using a DNA vaccine encoding the nucleoprotein of influenza from the 1934 H1N1 strain ( ). When infected with a lethal dose of influenza from a strain different from the strain from which the vaccine was made, immunized mice had a higher survival rate than did control mice immunized with a control ( ). This protection was mediated by cytolytic T lymphocytes that recognized portions of the nucleoprotein. . The strains from which the DNA vaccine was made ( ) and used to infect ( ) the mice. The influenza nucleoprotein was more highly conserved than the surface proteins. Reproduced with permission from the British Society for Immunology. Donnelly JJ, Ulmer JB, Liu MA. Immunization with polynucleotides. Immunology. 1994; 2:20-6.
Figure 2. . Survival rates among mice immunized against influenza by using a DNA vaccine encoding the nucleoprotein of influenza from the 1934 H1N1 strain ( ). When infected with a lethal dose of influenza from a strain different from the strain from which the vaccine was made, immunized mice had a higher survival rate than did control mice immunized with a control ( ). This protection was mediated by cytolytic T lymphocytes that recognized portions of the nucleoprotein. . The strains from which the DNA vaccine was made ( ) and used to infect ( ) the mice. The influenza nucleoprotein was more highly conserved than the surface proteins. Reproduced with permission from the British Society for Immunology. Donnelly JJ, Ulmer JB, Liu MA. Immunization with polynucleotides. Immunology. 1994; 2:20-6. Heterosubtypic protection.TopsquarescirclesBottomleftright

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  1. Ann Intern Med April 1, 2003 vol. 138 no. 7 550-559
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