Gene Vaccines[dhelix]

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Figure 1. Newly synthesized viral protein in the cytoplasm of an infected cell is degraded into peptides that are transported into the endoplasmic reticulum and then to the Golgi apparatus. Peptides bind to newly synthesized major histocompatibility complex class I molecules; the complex is then expressed on the surface of the cell where, in the presence of appropriate accessory molecules, binding to the T-cell receptor of CD8 cells can occur. This binding results in activation of the cytolytic T lymphocyte. Adapted from McDonnell and Askari , with permission from the Massachusetts Medical Society.
Figure 1. Newly synthesized viral protein in the cytoplasm of an infected cell is degraded into peptides that are transported into the endoplasmic reticulum and then to the Golgi apparatus. Peptides bind to newly synthesized major histocompatibility complex class I molecules; the complex is then expressed on the surface of the cell where, in the presence of appropriate accessory molecules, binding to the T-cell receptor of CD8 cells can occur. This binding results in activation of the cytolytic T lymphocyte. Adapted from McDonnell and Askari , with permission from the Massachusetts Medical Society. Activation of cytolytic T lymphocytes.+(2)

This Article

  1. Ann Intern Med April 1, 2003 vol. 138 no. 7 550-559
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