Changing Use of Antibiotics in Community-Based Outpatient Practice, 1991–1999

  1. Michael A. Steinman, MD;
  2. Ralph Gonzales, MD, MSPH;
  3. Jeffrey A. Linder, MD, MPH; and
  4. C. Seth Landefeld, MD
  1. From San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California; and Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
    1. Figure 1. Overall use of antibiotics decreased in adult visits for the common cold and unspecified upper respiratory tract infections ( s) ( = 0.011), for pharyngitis ( = 0.02), and for acute bronchitis ( < 0.001). Among adults receiving an antibiotic, broad-spectrum agents made up an increased proportion of antibiotic prescriptions for each condition shown (for pharyngitis, = 0.002; for all other conditions, < 0.001). (Results are shown at the level of the patient visit: Broad spectrum indicates visits involving at least one broad-spectrum antibiotic; narrow spectrum indicates visits involving only narrow-spectrum agents.) The mean number of visits occurring annually during the study period is shown for each condition. UTI = urinary tract infection.
      View larger version:
        Figure 1. Overall use of antibiotics decreased in adult visits for the common cold and unspecified upper respiratory tract infections ( s) ( = 0.011), for pharyngitis ( = 0.02), and for acute bronchitis ( < 0.001). Among adults receiving an antibiotic, broad-spectrum agents made up an increased proportion of antibiotic prescriptions for each condition shown (for pharyngitis, = 0.002; for all other conditions, < 0.001). (Results are shown at the level of the patient visit: Broad spectrum indicates visits involving at least one broad-spectrum antibiotic; narrow spectrum indicates visits involving only narrow-spectrum agents.) The mean number of visits occurring annually during the study period is shown for each condition. UTI = urinary tract infection. Antibiotic prescribing among adults between 1991–1992 and 1998–1999.URTIPPPPP
      • Figure 2. Overall use of antibiotics decreased in pediatric visits for the common cold and unspecified upper respiratory tract infections ( s) ( < 0.001) and for pharyngitis ( = 0.002). Among children receiving an antibiotic, broad-spectrum agents made up an increased proportion of antibiotic prescriptions for each condition shown (for values, see text). (Results are shown at the level of the patient visit: Broad spectrum indicates visits involving at least one broad-spectrum antibiotic; narrow spectrum indicates visits involving only narrow-spectrum agents.) The mean number of visits occurring annually during the study period is shown for each condition.
        View larger version:
          Figure 2. Overall use of antibiotics decreased in pediatric visits for the common cold and unspecified upper respiratory tract infections ( s) ( < 0.001) and for pharyngitis ( = 0.002). Among children receiving an antibiotic, broad-spectrum agents made up an increased proportion of antibiotic prescriptions for each condition shown (for values, see text). (Results are shown at the level of the patient visit: Broad spectrum indicates visits involving at least one broad-spectrum antibiotic; narrow spectrum indicates visits involving only narrow-spectrum agents.) The mean number of visits occurring annually during the study period is shown for each condition. Antibiotic prescribing among children between 1991–1992 and 1998–1999.URTIPPP
        • Figure 3. Among adults, use of broad-spectrum agents increased for urinary tract infections ( s) and for the common cold and unspecified upper respiratory tract infections ( s) ( < 0.001 for both conditions). Among children, use of broad-spectrum agents increased for otitis media ( = 0.044) and for the common cold and URTIs ( < 0.001).
          View larger version:
            Figure 3. Among adults, use of broad-spectrum agents increased for urinary tract infections ( s) and for the common cold and unspecified upper respiratory tract infections ( s) ( < 0.001 for both conditions). Among children, use of broad-spectrum agents increased for otitis media ( = 0.044) and for the common cold and URTIs ( < 0.001). Use of broad-spectrum antibiotics for selected conditions.UTIURTIPPP

          Summary for Patients

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