Implantable Cardioverter Defibrillators in Primary and Secondary Prevention

  1. Justin A. Ezekowitz, MB, BCh;
  2. Paul W. Armstrong, MD, FRCPC; and
  3. Finlay A. McAlister, MD, MSc, FRCPC
  1. From the University of Alberta, Edmonton, Alberta, Canada.
    1. Figure 1. RCT = randomized, controlled trial.
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      Figure 1. RCT = randomized, controlled trial. Selection of trials included in the meta-analysis.
    2. Figure 2. Relative risk ( ) is shown with box size proportional to sample size; lines indicate 95% CIs. For each stratum, the diamond represents the pooled analysis. AVID = Antiarrhythmic versus Implantable Defibrillator; CABG Patch = Coronary Artery Bypass Graft Patch Trial; CASH = Cardiac Arrest Study Hamburg; CAT = Cardiomyopathy Trial; CIDS = Canadian Implantable Defibrillator Study; ICD = implantable cardioverter defibrillator; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MADIT II = Multicenter Automatic Defibrillator Implantation Trial II; MUSTT = Multicenter Unsustained Tachycardia Trial.
      View larger version:
      Figure 2. Relative risk ( ) is shown with box size proportional to sample size; lines indicate 95% CIs. For each stratum, the diamond represents the pooled analysis. AVID = Antiarrhythmic versus Implantable Defibrillator; CABG Patch = Coronary Artery Bypass Graft Patch Trial; CASH = Cardiac Arrest Study Hamburg; CAT = Cardiomyopathy Trial; CIDS = Canadian Implantable Defibrillator Study; ICD = implantable cardioverter defibrillator; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MADIT II = Multicenter Automatic Defibrillator Implantation Trial II; MUSTT = Multicenter Unsustained Tachycardia Trial. Sudden cardiac death for included trials.RR
    3. Figure 3. Relative risk ( ) is shown with box size proportional to sample size; lines indicate 95% CIs. For each stratum, the diamond represents the pooled analysis. AVID = Antiarrhythmic versus Implantable Defibrillator; CABG Patch = Coronary Artery Bypass Graft Patch Trial; CASH = Cardiac Arrest Study Hamburg; CAT = Cardiomyopathy Trial; CIDS = Canadian Implantable Defibrillator Study; ICD = implantable cardioverter defibrillator; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MADIT II = Multicenter Automatic Defibrillator Implantation Trial II; MUSTT = Multicenter Unsustained Tachycardia Trial.
      View larger version:
      Figure 3. Relative risk ( ) is shown with box size proportional to sample size; lines indicate 95% CIs. For each stratum, the diamond represents the pooled analysis. AVID = Antiarrhythmic versus Implantable Defibrillator; CABG Patch = Coronary Artery Bypass Graft Patch Trial; CASH = Cardiac Arrest Study Hamburg; CAT = Cardiomyopathy Trial; CIDS = Canadian Implantable Defibrillator Study; ICD = implantable cardioverter defibrillator; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MADIT II = Multicenter Automatic Defibrillator Implantation Trial II; MUSTT = Multicenter Unsustained Tachycardia Trial. All-cause mortality for included trials.RR

    Summary for Patients

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