Postmenopausal Hormone Replacement Therapy and the Primary Prevention of Cardiovascular Disease

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   Figure 1. Error bars represent 95% CIs. HRT = hormone replacement therapy. “Current,” “past,” and “ever” use are categories used in the individual studies. “Any use” is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use). Relative risk or odds ratio for cardiovascular disease mortality.
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   Figure 2. Error bars represent 95% CIs. HRT = hormone replacement therapy. “Current,” “past,” and “ever” use are categories used in the individual studies. “Any use” is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use). Relative risk or odds ratio for coronary artery disease mortality.
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   Figure 3. Error bars represent 95% CIs. Reference is pooled data from a previously published meta-analysis. HRT = hormone replacement therapy. “Current,” “past,” and “ever” use are categories used in the individual studies. “Any use” is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use). Relative risk or odds ratio for cardiovascular disease incidence.47
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   Figure 4. Error bars represent 95% CIs. HRT = hormone replacement therapy; RCT = randomized, controlled trial; SES = socioeconomic status. “Current,” “past,” and “ever” use are categories used in the individual studies. “Any use” is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use). Adjustments for SES were adjustments as assessed by social class , education , and income. Relative risk or odds ratio for coronary artery disease incidence.(12, 13)(14, 15)
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   Appendix Figure. Search methods and results. HRT = hormone replacement therapy; RCT = randomized, controlled trial.

• Copyright ©2004 by the American College of Physicians