Acquired Aplastic Anemia

Figure 4. Activated T cells, shown as enlarged, attack and destroy hematopoietic stem-cell targets. Some drugs inhibit lymphocyte function. Others are broadly lymphocytotoxic. Laboratory and animal data show that agents relatively selective for activated lymphocytes can induce tolerance by eliminating functionally active T-cell clones. Antithymocyte globulin, cyclosporine, and cyclophosphamide have been used to treat aplastic anemia, alone and in combination.
Figure 4. Activated T cells, shown as enlarged, attack and destroy hematopoietic stem-cell targets. Some drugs inhibit lymphocyte function. Others are broadly lymphocytotoxic. Laboratory and animal data show that agents relatively selective for activated lymphocytes can induce tolerance by eliminating functionally active T-cell clones. Antithymocyte globulin, cyclosporine, and cyclophosphamide have been used to treat aplastic anemia, alone and in combination. Immunosuppressive therapies.

This Article

  1. Ann Intern Med April 2, 2002 vol. 136 no. 7 534-546
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