Table of Contents

April 2, 2002; 136 (7)

Articles

  • Effect of Aerobic Exercise on Blood Pressure: A Meta-Analysis of Randomized, Controlled Trials

    • Seamus P. Whelton,
    • Ashley Chin,
    • Xue Xin,
    • and Jiang He
    Ann Intern Med April 2, 2002 136:493-503

    Exercise reduces blood pressure in both hypertensive and normotensive persons. An increase in aerobic physical activity should be considered an important component of lifestyle modification for prevention and treatment of high blood pressure.

  • Administration of Neutral Protamine Hagedorn Insulin at Bedtime versus with Dinner in Type 1 Diabetes Mellitus To Avoid Nocturnal Hypoglycemia and Improve Control: A Randomized, Controlled Trial

    • Carmine G. Fanelli,
    • Simone Pampanelli,
    • Francesca Porcellati,
    • Paolo Rossetti,
    • Paolo Brunetti,
    • and Geremia B. Bolli
    Ann Intern Med April 2, 2002 136:504-514

    When the goal of insulin therapy in type 1 diabetes mellitus is near-normoglycemia, splitting the evening insulin treatment regimen into short-acting insulin at dinner and neutral protamine Hagedorn (NPH) insulin at bedtime reduces the risks for nocturnal hypoglycemia and hypoglycemia unawareness and decreases the hemoglobin A1c value compared with mixing short-acting insulin and NPH insulin at dinner.

  • Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension

    • Hossein Ardeschir Ghofrani,
    • Ralph Wiedemann,
    • Frank Rose,
    • Horst Olschewski,
    • Ralph Theo Schermuly,
    • Norbert Weissmann,
    • Werner Seeger,
    • and Friedrich Grimminger
    Ann Intern Med April 2, 2002 136:515-522

    Although limited by the small sample and lack of long-term observations, this study shows that oral sildenafil is a potent pulmonary vasodilator that acts synergistically with inhaled iloprost to cause pulmonary vasodilatation in both severe pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Brief Communications

  • Change in Coronary Flow Reserve on Transthoracic Doppler Echocardiography after a Single High-Fat Meal in Young Healthy Men

    • Takeshi Hozumi,
    • Marc Eisenberg,
    • Kenichi Sugioka,
    • Aravind R. Kokkirala,
    • Hiroyuki Watanabe,
    • Masakazu Teragaki,
    • Junichi Yoshikawa,
    • and Shunichi Homma
    Ann Intern Med April 2, 2002 136:523-528

    In this study, coronary flow reserve decreased after a single high-fat meal in young healthy men. High-fat meals may be detrimental to coronary microcirculation.

  • Is C-Reactive Protein Specific for Vascular Disease in Women?

    • Nader Rifai,
    • Julie E. Buring,
    • I-Min Lee,
    • JoAnn E. Manson,
    • and Paul M Ridker
    Ann Intern Med April 2, 2002 136:529-533

    C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic persons. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain. This study found that CRP level appears to independently predict cardiovascular events but not cancer.

Updates

  • Acquired Aplastic Anemia

    • Neal S. Young
    Ann Intern Med April 2, 2002 136:534-546

    This Update discusses many aspects of aplastic anemia, including its immune pathophysiology, its place as a hematologic disease and as an immune-mediated syndrome, the differential diagnosis of bone marrow failure, the possibility of an infectious cause, available treatments, and evolution to other hematologic diseases and late clonal events.

Editorials

  • Avoiding Nocturnal Hypoglycemia: Consideration of an Extra Injection at Bedtime

    • Andrew W. Norris and
    • Lori M.B. Laffel
    Ann Intern Med April 2, 2002 136:547-549

    In this issue, Fanelli and colleagues compared split-dose and mixed-dose insulin regimens in patients with type 1 diabetes mellitus. Evidence now suggests that for a selected group of persons with type 1 diabetes mellitus, an extra shot at bedtime should be considered, although newer insulin analogues may yield additional approaches and benefits in the near future.

  • C-Reactive Protein Risk Prediction: Low Specificity, High Sensitivity

    • Wolfgang Koenig and
    • Mark B. Pepys
    Ann Intern Med April 2, 2002 136:550-552

    Consistent results from more than 15 well-conducted prospective studies in initially healthy persons have shown a strong and independent association between the circulating C-reactive protein level and cardiovascular end points. As Rifai and colleagues show in this issue, the empirical measurement of C-reactive protein is a powerful predictor of cardiovascular risk regardless of the underlying mechanisms.

  • Welcome, PIER, A New Physicians' Information and Education Resource

    • Robert G. Badgett and
    • Cynthia D. Mulrow
    Ann Intern Med April 2, 2002 136:553-554

    PIER (Physicians' Information and Education Resource), a new information product for the clinician, will be available beginning April 11 to American College of Physicians–American Society of Internal Medicine members (http://πer.acponline.org/). PIER represents a new direction in medical publishing because it will help clinicians address complex, multifaceted questions in an informed manner.

Letters

  • Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia

    • Paul Moayyedi,
    • Jonathan Deeks,
    • and David Forman
    Ann Intern Med April 2, 2002 136:555

  • Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia

    • Ward B. Buckingham
    Ann Intern Med April 2, 2002 136:555

  • Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia

    • John M. Bozdech
    Ann Intern Med April 2, 2002 136:555-556

  • Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia

    • Loren Laine,
    • M. Brian Fennerty,
    • and Philip Schoenfeld
    Ann Intern Med April 2, 2002 136:556

  • Acute Exacerbations of Chronic Obstructive Pulmonary Disease

    • Claudia Stey
    Ann Intern Med April 2, 2002 136:556-557

  • Acute Exacerbations of Chronic Obstructive Pulmonary Disease

    • Michael S. Niederman,
    • Sanjay Sethi,
    • and Fernando Martinez
    Ann Intern Med April 2, 2002 136:557

  • Acute Exacerbations of Chronic Obstructive Pulmonary Disease

    • Vincenza Snow
    Ann Intern Med April 2, 2002 136:557-558

  • Laser Removal of Radiation Tattoos

    • Murad Alam and
    • Kenneth A. Arndt
    Ann Intern Med April 2, 2002 136:558

Medical Writings

  • Putting Ethics into the Medical Record

    • Alfred I. Tauber
    Ann Intern Med April 2, 2002 136:559-563

    Consider an addition to the medical record—one that heretofore was implicitly present but now must be made explicit: Insert a section called Ethical Concerns.

Medical Writings: Book Notes

Ad Libitum

Book Listings

Medical Notices

Summaries for Patients

  • Exercise Lowers Blood Pressure

    Ann Intern Med April 2, 2002 136:I16

  • Splitting the Evening Insulin Dose To Avoid Low Blood Sugar Levels and To Improve Sugar Control in Patients with Type 1 Diabetes

    Ann Intern Med April 2, 2002 136:I29

  • Sildenafil (Viagra) May Help Improve Control of Pulmonary Hypertension

    Ann Intern Med April 2, 2002 136:I35

  • How a High-Fat Meal Affects Blood Flow to the Heart

    Ann Intern Med April 2, 2002 136:I41

  • Is C-Reactive Protein Specific for Vascular Disease in Women?

    Ann Intern Med April 2, 2002 136:I42
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This Issue

April 2, 2002; 136 (7)
  1. Articles
  2. Brief Communications
  3. Updates
  4. Editorials
  5. Letters
  6. Medical Writings
  7. Medical Writings: Book Notes
  8. Ad Libitum
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients

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