Future Directions in the Study and Management of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Figure 5. Fludrocortisone is given in the usual manner. The hydrocortisone dose is reduced to physiologic levels, resulting
in elevated androgen production. An antiandrogen agent is administered to block the effect of the elevated androgen levels,
and an inhibitor of androgen-to-estrogen conversion is given to block conversion of the increased amount of androgen to estrogen.
An investigational approach to the treatment of classic congenital adrenal hyperplasia.
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Ann Intern Med
February 19, 2002
vol. 136
no. 4
320-334