Future Directions in the Study and Management of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Figure 4. The treatment outcome in classic congenital adrenal hyperplasia is often suboptimal because of incomplete suppression of hyperandrogenism ( ), treatment-induced hypercortisolism ( ), or both. At 16 years of age, a female patient with salt-losing 21-hydroxylase deficiency due to undertreatment with glucocorticoid and elevated androgen levels had hirsutism, acne, amenorrhea, and hyperpigmentation ( ). Increased glucocorticoid treatment resulted in weight gain with cushingoid features and short stature in a male patient with classic 21-hydroxylase deficiency ( ).
Figure 4. The treatment outcome in classic congenital adrenal hyperplasia is often suboptimal because of incomplete suppression of hyperandrogenism ( ), treatment-induced hypercortisolism ( ), or both. At 16 years of age, a female patient with salt-losing 21-hydroxylase deficiency due to undertreatment with glucocorticoid and elevated androgen levels had hirsutism, acne, amenorrhea, and hyperpigmentation ( ). Increased glucocorticoid treatment resulted in weight gain with cushingoid features and short stature in a male patient with classic 21-hydroxylase deficiency ( ). Patients with salt-losing 21-hydroxylase deficiency.topbottomtopbottom

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  1. Ann Intern Med February 19, 2002 vol. 136 no. 4 320-334
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