Table of Contents

October 2, 2001; 135 (7)

Articles

  • Durable Treatment-Free Remission after High-Dose Cyclophosphamide Therapy for Previously Untreated Severe Aplastic Anemia

    • Robert A. Brodsky,
    • Lyle L. Sensenbrenner,
    • B. Douglas Smith,
    • Donna Dorr,
    • Phillip J. Seaman,
    • Shing M. Lee,
    • Judith E. Karp,
    • Isadore Brodsky,
    • and Richard J. Jones
    Ann Intern Med October 2, 2001 135:477-483

    High-dose cyclophosphamide therapy without bone marrow transplantation produces durable treatment-free remission in severe aplastic anemia. This approach deserves further study in patients with severe aplastic anemia who are not suitable candidates for allogeneic bone marrow transplantation.

  • Determinants of Vancomycin Resistance and Mortality Rates in Enterococcal Bacteremia: A Prospective Multicenter Study

    • Emanuel N. Vergis,
    • Mary K. Hayden,
    • Joseph W. Chow,
    • David R. Snydman,
    • Marcus J. Zervos,
    • Peter K. Linden,
    • Marilyn M. Wagener,
    • Barbara Schmitt,
    • and Robert R. Muder
    Ann Intern Med October 2, 2001 135:484-492

    Vancomycin resistance is an independent predictor of death from enterococcal bacteremia. Early, effective antimicrobial therapy is associated with significant improvement in survival.

  • Effect of Estrogen plus Progestin on Risk for Biliary Tract Surgery in Postmenopausal Women with Coronary Artery Disease: The Heart and Estrogen/progestin Replacement Study

    • Joel A. Simon,
    • Donald B. Hunninghake,
    • Sanjay K. Agarwal,
    • Feng Lin,
    • Jane A. Cauley,
    • Christine C. Ireland,
    • James H. Pickar,
    • and for the Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    Ann Intern Med October 2, 2001 135:493-501

    Estrogen plus progestin therapy among postmenopausal women with known coronary disease resulted in a small, marginally significant increase in the risk for biliary tract surgery.

Brief Communications

  • Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis

    • Theodore E. Warkentin and
    • John G. Kelton
    Ann Intern Med October 2, 2001 135:502-506

    Delayed-onset heparin-induced thrombocytopenia should be suspected when patients present with thrombocytopenia and thrombosis up to 3 weeks after exposure to heparin. This syndrome could be caused by high titers of platelet-activating IgG induced by heparin.

Academia and Clinic

  • Alternative Medicine: A “Mirror Image” for Scientific Reasoning in Conventional Medicine

    • Jan P. Vandenbroucke and
    • Anton J.M. de Craen
    Ann Intern Med October 2, 2001 135:507-513

    The scientific behavior of adherents of conventional medicine toward one form of alternative medicine—homeopathy—suggests that physicians may reject seemingly solid evidence because it is not compatible with theory. Further reflection, however, shows that physicians do the same within conventional medical science: Sometimes they discard a theory because of new facts, but other times they cling to a theory despite the facts.

Medicine and Public Issues

  • Core Safeguards for Clinical Research with Adults Who Are Unable To Consent

    • Dave Wendler and
    • Kiran Prasad
    Ann Intern Med October 2, 2001 135:514-523

    The National Bioethics Advisory Commission has recently proposed new safeguards for clinical research with adults who are unable to consent. Three other major U.S. groups have also proposed additional safeguards, and existing Canadian and European guidelines already include such safeguards. This paper compares the guidelines, highlights their major points of consensus, analyzes their significant differences, and distills six core safeguards.

Position Papers

  • Guidelines for the Management of Patients with Chronic Stable Angina: Diagnosis and Risk Stratification

    • Sankey V. Williams,
    • Stephan D. Fihn,
    • and Raymond J. Gibbons
    Ann Intern Med October 2, 2001 135:530-547

    This article is the first of two papers about the care of patients with chronic stable angina. Both articles have been adapted from materials created by the American College of Cardiology, the American Heart Association, and the American College of Physicians–American Society of Internal Medicine. The adaptations in these articles are intended to make the information more useful for clinicians who do not specialize in the care of patients with heart disease.

Editorials

  • Aplastic Anemia: Which Treatment?

    • Janis L. Abkowitz
    Ann Intern Med October 2, 2001 135:524-526

    In this issue, Brodsky and colleagues report on a new option for initial treatment of aplastic anemia: high-dose cyclophosphamide without allogeneic hematopoietic stem cells. Survival at 2 years was 84%. Although the study was small and uncontrolled, the data are provocative.

  • Implications and Challenges Using Practice Guidelines for Chronic Angina

    • E. Magnus Ohman and
    • Eric Peterson
    Ann Intern Med October 2, 2001 135:527-529

    In this issue and a subsequent issue, two papers present an abbreviated outline of the complete guidelines for the management of patients with chronic stable angina. Guidelines are the first step to synthesizing the evidence and taking advantage of excellent cardiovascular clinical trials and the collective wisdom achieved from careful clinical observation over the past several decades.

Letters

  • Prevention of Bleeding in Older Patients Taking Warfarin

    • Alex C. Spyropoulos
    Ann Intern Med October 2, 2001 135:548

  • Prevention of Bleeding in Older Patients Taking Warfarin

    • Samuel Kajubi
    Ann Intern Med October 2, 2001 135:548-549

  • Prevention of Bleeding in Older Patients Taking Warfarin

    • Rebecca J. Beyth and
    • C. Seth Landefeld
    Ann Intern Med October 2, 2001 135:549

  • Inflation of Precision in Medical Reports

    • Glen L. Hortin
    Ann Intern Med October 2, 2001 135:549

  • Severe Liver Injury

    • Maria Torres and
    • K. Rajender Reddy
    Ann Intern Med October 2, 2001 135:550

  • Correction: Ivermectin Dose in Update in Dermatology

    Ann Intern Med October 2, 2001 135:550

  • Correction: Sprout-Associated Infections

    Ann Intern Med October 2, 2001 135:550

Medical Writings

  • “I Wish Things Were Different”: Expressing Wishes in Response to Loss, Futility, and Unrealistic Hopes

    • Timothy E. Quill,
    • Robert M. Arnold,
    • and Frederic Platt
    Ann Intern Med October 2, 2001 135:551-555

    In emotionally challenging situations, many physicians attempt to respond empathically by stating “I'm sorry.” Although frequently appropriate, this phrase may be misinterpreted and misdirected. Saying “I wish … (things were different)” to the patient and family is a more effective initial response. This paper explicates some of the challenges of saying “I'm sorry” and explores the potential benefits of saying “I wish …” in difficult clinical scenarios.

Medical Writings: Book Notes

Book Listings

Medical Notices

Summaries for Patients

  • High-Dose Cyclophosphamide To Treat Severe Aplastic Anemia

    Ann Intern Med October 2, 2001 135:S42

  • Determinants of Vancomycin Resistance and Death in Enterococcal Bacteremia

    Ann Intern Med October 2, 2001 135:S43

  • Hormone Replacement Therapy in Postmenopausal Women with Heart Disease and Risk for Gallstones That Require Surgery

    Ann Intern Med October 2, 2001 135:S44

  • Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis

    Ann Intern Med October 2, 2001 135:S45
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This Issue

October 2, 2001; 135 (7)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Medicine and Public Issues
  5. Position Papers
  6. Editorials
  7. Letters
  8. Medical Writings
  9. Medical Writings: Book Notes
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients

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