Table of Contents

September 18, 2001; 135 (6)

Articles

  • Clinical Predictors of Prolonged Delay in Return of the International Normalized Ratio to within the Therapeutic Range after Excessive Anticoagulation with Warfarin

    • Elaine M. Hylek,
    • Susan Regan,
    • Alan S. Go,
    • Robert A. Hughes,
    • Daniel E. Singer,
    • and Steven J. Skates
    Ann Intern Med September 18, 2001 135:393-400

    Steady-state warfarin dose, advanced age, and extreme elevation in international normalized ratio (INR) are risk factors for prolonged delay in return of the INR to within the therapeutic range. Decompensated congestive heart failure and active cancer greatly increase this risk.

  • Diagnostic Tests for Renal Artery Stenosis in Patients Suspected of Having Renovascular Hypertension: A Meta-Analysis

    • G. Boudewijn C. Vasbinder,
    • Patricia J. Nelemans,
    • Alfons G.H. Kessels,
    • Abraham A. Kroon,
    • Peter W. de Leeuw,
    • and Jos M.A. van Engelshoven
    Ann Intern Med September 18, 2001 135:401-411

    Computed tomography angiography and gadolinium-enhanced three-dimensional magnetic resonance angiography seem to be preferred in patients referred for evaluation of renovascular hypertension. However, because few studies of these tests have been published, further research is recommended.

  • Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy: A Randomized, Controlled Trial

    • Marc Boogaerts,
    • Drew J. Winston,
    • Eric J. Bow,
    • Gary Garber,
    • Annette C. Reboli,
    • Anthony P. Schwarer,
    • Nicolas Novitzky,
    • Angelika Boehme,
    • Elisabeth Chwetzoff,
    • Karel De Beule,
    • and the Itraconazole Neutropenia Study Group*
    Ann Intern Med September 18, 2001 135:412-422

    Itraconazole and amphotericin B have at least equivalent efficacy when used as empirical antifungal therapy in neutropenic patients with cancer. However, itraconazole is associated with significantly less toxicity.

  • Sustained-Release Bupropion for Pharmacologic Relapse Prevention after Smoking Cessation: A Randomized, Controlled Trial

    • J. Taylor Hays,
    • Richard D. Hurt,
    • Nancy A. Rigotti,
    • Raymond Niaura,
    • David Gonzales,
    • Michael J. Durcan,
    • David P.L. Sachs,
    • Troy D. Wolter,
    • A. Sonia Buist,
    • J. Andrew Johnston,
    • and Jonathan D. White
    Ann Intern Med September 18, 2001 135:423-433

    In persons who had stopped smoking during 7 weeks of bupropion treatment, sustained-release bupropion for 12 months delayed smoking relapse and resulted in less weight gain compared with patients who received placebo.

Brief Communications

  • Fatal Pseudomembranous Colitis Associated with a Variant Clostridium difficile Strain Not Detected by Toxin A Immunoassay

    • Stuart Johnson,
    • Sara A. Kent,
    • Kevin J. O'Leary,
    • Michelle M. Merrigan,
    • Susan P. Sambol,
    • Lance R. Peterson,
    • and Dale N. Gerding
    Ann Intern Med September 18, 2001 135:434-438

    Toxin A variant strains of Clostridium difficile cause serious disease and are undetectable in clinical laboratories that use only toxin A immunoassays for C. difficile testing.

Updates

  • Hypertriglyceridemic HyperapoB: The Unappreciated Atherogenic Dyslipoproteinemia in Type 2 Diabetes Mellitus

    • Allan D. Sniderman,
    • Thea Scantlebury,
    • and Katherine Cianflone
    Ann Intern Med September 18, 2001 135:447-459

    The authors review the pathophysiology of hypertriglyceridemic hyperapoB, focusing on the changes in lipoprotein particle number and composition rather than lipoprotein lipid levels; summarize the in vitro and in vivo evidence that small, dense low-density lipoprotein (LDL) are more atherogenic than normal larger, buoyant LDL; and delineate the particularly high-risk state conferred by increased numbers of small, dense LDL.

Editorials

  • Managing Excessive Warfarin Anticoagulation

    • Henry I. Bussey
    Ann Intern Med September 18, 2001 135:460-462

    In this issue, Hylek and colleagues provide valuable new information that should improve the ability to manage excessive warfarin anticoagulation and reduce risk for bleeding. In the absence of more definitive data from prospective studies, this study may help physicians decide who should receive vitamin K, how much vitamin K is required, and how soon a follow-up international normalized ratio is indicated.

  • Sponsorship, Authorship, and Accountability

    • Frank Davidoff,
    • Catherine D. DeAngelis,
    • Jeffrey M. Drazen,
    • The Editors,
    • John Hoey,
    • Liselotte Højgaard,
    • Richard Horton,
    • Sheldon Kotzin,
    • Magne Nylenna,
    • A. John P.M. Overbeke,
    • Harold C. Sox,
    • Martin B. Van Der Weyden,
    • and Michael S. Wilkes
    Ann Intern Med September 18, 2001 135:463-466

    The authors of this editorial belong to the International Committee of Medical Journal Editors (ICMJE). They ask investigators to use the revised ICMJE requirements on publication ethics to guide the negotiation of contracts with corporate sponsors of research. Those contracts should give the researchers a substantial say in trial design, access to the raw data, responsibility for data analysis and interpretation, and the right to publish. The co-signers of this editorial are unlikely to publish articles when the authors did not enjoy these basic rights.

On Being a Doctor

  • Pronouncing

    • Brendan M. Reilly
    Ann Intern Med September 18, 2001 135:467-470

    Looking back now, knowing what I know today about this place, it is easy to feel naive or stupid about what happened that night at Charlie's house. But this was 25 years ago, so I will tell you what I saw that night and how it strikes me now. But I may never know what really happened.

Letters

  • Erythropoietin for Total Hip Joint Arthroplasty

    • John T. Kontor
    Ann Intern Med September 18, 2001 135:471

  • Erythropoietin for Total Hip Joint Arthroplasty

    • Brian G. Feagan
    Ann Intern Med September 18, 2001 135:471

Medical Writings: Book Notes

Current Clinical Issues

  • Prognostic Models Abound, but How Useful Are They?

    • Tom Reynolds
    Ann Intern Med September 18, 2001 135:473-476

Ad Libitum

Book Listings

Medical Notices

Summaries for Patients

  • Predicting Risk for Prolonged High INR after Too Much Anticoagulation

    Ann Intern Med September 18, 2001 135:S37

  • Diagnosis of Renal Artery Stenosis

    Ann Intern Med September 18, 2001 135:S38

  • Itraconazole and Amphotericin B To Treat Fungal Infections in Patients with Cancer Who Are Receiving Chemotherapy

    Ann Intern Med September 18, 2001 135:S39

  • Bupropion To Prevent Relapse in People Who Quit Cigarette Smoking

    Ann Intern Med September 18, 2001 135:S40

  • Fatal Inflammatory Condition in a Patient with a Variant Bacterial Strain

    Ann Intern Med September 18, 2001 135:S41

Updates from the Annual Session

  • Update in Cardiology

    • William H. Frishman
    Ann Intern Med September 18, 2001 135:439-446

    This year's Update in Cardiology features key reports in major areas of cardiovascular medicine: prevention, unstable coronary syndromes, chronic cardiovascular disease, arrhythmias, and peripheral vascular disease.

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This Issue

September 18, 2001; 135 (6)
  1. Articles
  2. Brief Communications
  3. Updates
  4. Editorials
  5. On Being a Doctor
  6. Letters
  7. Medical Writings: Book Notes
  8. Current Clinical Issues
  9. Ad Libitum
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients
  13. Updates from the Annual Session

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