Table of Contents

August 21, 2001; 135 (4)

Articles

  • Postmenopausal women taking hormone replacement therapy have a smaller increase in systolic blood pressure over time than those not taking this therapy. This difference is intensified at older ages.

  • In California, from 1996 through 1998, more than 50% of multicounty outbreaks with confirmed food vehicles were related to alfalfa or clover sprouts. This summary of the investigations of these outbreaks indicates that sprouts can be a hazardous food. Seed and sprout growers should implement measures to decrease contamination, and the general public should recognize the risks of eating sprouts.

  • With extended follow-up, pulse cyclophosphamide continued to show superior efficacy over pulse methylprednisolone alone for treatment of lupus nephritis. The combination of pulse cyclophosphamide and methylprednisolone appears to provide additional benefit over pulse cyclophosphamide alone and does not confer additional risk for adverse events.

Brief Communications

  • Resolution of hypertension after adrenalectomy for primary aldosteronism is independently associated with a lack of family history of hypertension and preoperative use of two or fewer antihypertensive agents.

Academia and Clinic

  • Although recent research has shown that many people in the United States use complementary and alternative medical (CAM) therapies, little is known about time trends in use. These authors found that use of CAM therapies by a large proportion of the study sample is the result of a secular trend that began at least a half-century ago. This trend suggests a continuing demand for CAM therapies that will affect health care delivery for the foreseeable future.

Review

  • The authors review the migration of labeled T-cell subsets in unmanipulated animals, discuss the relevance of these findings to the clinical outcome of anti–adhesion-molecule therapy, and outline how these observations may help us better understand T-cell–mediated diseases and develop new therapeutic strategies.

Editorial

  • In this issue, Illei and colleagues report on a clinical trial of lupus nephritis that compared parenteral methylprednisolone, parenteral cyclophosphamide, and a combination of these two treatments, all in addition to low-dose oral prednisone. Their study raised hope that a more definitive answer to ideal therapy is on the horizon. Unfortunately, the study has important limitations.

Letters

Medical Writings: Book Notes

Current Clinical Issues

Book Listings

Medical Notices

Summaries for Patients

Updates from the Annual Session

  • This year's Update in General Internal Medicine spans a wide area but fits into a framework of the following themes: hypertension, hormone replacement therapy, anticoagulation, atrial fibrillation, chronic infectious diseases, hospital care, and prevention.