Table of Contents

April 3, 2001; 134 (7)

Articles

  • The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis

    • David T. Felson,
    • Christine E. Chaisson,
    • Catherine L. Hill,
    • Saara M.S. Totterman,
    • M. Elon Gale,
    • Katherine M. Skinner,
    • Lewis Kazis,
    • and Daniel R. Gale
    Ann Intern Med April 3, 2001 134:541-549

    Bone marrow lesions on magnetic resonance imaging are strongly associated with the presence of pain in knee osteoarthritis.

  • β-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis

    • James M. Brophy,
    • Lawrence Joseph,
    • and Jean L. Rouleau
    Ann Intern Med April 3, 2001 134:550-560

    β-Blocker therapy is associated with clinically meaningful reductions in mortality and morbidity in patients with stable congestive heart failure and should be routinely offered to all patients who are similar to those included in trials.

  • Risk for Fracture in Women with Low Serum Levels of Thyroid-Stimulating Hormone

    • Douglas C. Bauer,
    • Bruce Ettinger,
    • Michael C. Nevitt,
    • Katie L. Stone,
    • and for the Study of Osteoporotic Fractures Research Group
    Ann Intern Med April 3, 2001 134:561-568

    Women older than 65 years of age who have low serum thyroid-stimulating hormone (TSH) levels, which indicate physiologic hyperthyroidism, are at increased risk for new hip and vertebral fractures. Use of thyroid hormone itself does not increase risk for fracture if TSH levels are normal.

Brief Communications

  • Confounding by Contraindication in a Nationwide Cohort Study of Risk for Death in Patients Taking Ibopamine

    • Hans Feenstra,
    • Rick E. Grobbee,
    • Bas A. in't Veld,
    • and Bruno H.Ch. Stricker
    Ann Intern Med April 3, 2001 134:569-572

    Outcomes may differ in treated and untreated patients as a result of a contraindication for treatment in untreated patients that is independently associated with the outcome of interest. This study evaluated the effects of confounding by contraindication on risk factors for death in patients taking ibopamine after use of the drug was restricted in the Netherlands.

Review

  • Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications

    • Valeria Santini,
    • Hagop M. Kantarjian,
    • and Jean-Pierre Issa
    Ann Intern Med April 3, 2001 134:573-586

    The authors review the biological rationale for targeting aberrant methylation in cancer therapy and summarize completed phase I and II trials of this approach, some of which show promise for treatment of hematologic malignancies.

Perspectives

  • Pseudoaccountability

    • Jerome P. Kassirer
    Ann Intern Med April 3, 2001 134:587-590

    When it comes to setting standards of accountability and ethical behavior, medical institutions and professional organizations have often faltered. In the guise of accountability, their efforts have often yielded lax standards that were intentionally and flagrantly self-serving. This is pseudoaccountability.

Position Papers

  • Evidence Base for Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

    • Vincenza Snow,
    • Steven Lascher,
    • Christel Mottur-Pilson,
    • and for the Joint Expert Panel on Chronic Obstructive Pulmonary Disease of the American College of Chest Physicians and the American College of Physicians–American Society of Internal Medicine*
    Ann Intern Med April 3, 2001 134:595-599

    This guideline presents the available evidence on risk stratification for relapse of chronic obstructive pulmonary disease (COPD) and 6-month mortality rates, diagnostic testing for acute exacerbations of COPD, and current treatment options for acute exacerbations of COPD.

  • Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Summary and Appraisal of Published Evidence

    • Peter B. Bach,
    • Cynthia Brown,
    • Sarah E. Gelfand,
    • and Douglas C. McCrory
    Ann Intern Med April 3, 2001 134:600-620

    The primary aims of this paper are 1) to summarize and evaluate published data that address care of patients with acute exacerbations of chronic obstructive pulmonary disease and 2) to improve the care that these patients receive by identifying efficacious and inefficacious treatments. This paper provides the background evidence for the clinical practice guideline in this issue.

Editorial

  • Edema of the Bone Marrow Can Cause Pain in Osteoarthritis and Other Diseases of Bone and Joints

    • Alfred Jay Bollet
    Ann Intern Med April 3, 2001 134:591-593

    In this issue, Felson and colleagues describe edema in the subarticular bone marrow adjacent to the knee in patients with painful knee osteoarthritis. This finding suggests that edematous changes in the subcortical bone marrow are one of the many sources of pain in patients with osteoarthritis. At present, this observation helps more in considering measures to minimize the stimuli that produce the pain rather than in treating pain once it develops.

On Being a Doctor

  • Nobility

    • James S. Goodwin
    Ann Intern Med April 3, 2001 134:621-622

    Whatever my initial emotional reaction to patients, it is difficult for me to dislike any of them for a prolonged period. I get to know them too well. They become far too interesting.

On Being a Patient

  • Fathers, Doctors, and Time

    • Emil P. Lesho
    Ann Intern Med April 3, 2001 134:623-624

    This year, the anniversary of my father's death hurt more than ever. I began to wonder how often I appeared to the children of my seriously ill patients like the doctors who took care of my father when I was a boy.

Letters

  • Adherence to Protease Inhibitors

    • Rita Murri,
    • Adriana Ammassari,
    • and Andrea Antinori
    Ann Intern Med April 3, 2001 134:625

  • Adherence to Protease Inhibitors

    • David L. Paterson and
    • Nina Singh
    Ann Intern Med April 3, 2001 134:625

  • Cost–Utility Analysis

    • Gary C. Brown,
    • Melissa M. Brown,
    • and Sanjay Sharma
    Ann Intern Med April 3, 2001 134:625-626

  • Cost–Utility Analysis

    • Peter J. Neumann,
    • Richard H. Chapman,
    • and Patricia W. Stone
    Ann Intern Med April 3, 2001 134:626

  • Giant-Cell Arteritis of the Female Genital Tract

    • Marc Paccalin,
    • Gwenael Le Moal,
    • and Pascal Roblot
    Ann Intern Med April 3, 2001 134:626-627

Medical Writings: Book Notes

  • The Transplant Patient: Biological, Psychiatric, and Ethical Issues in Organ Transplantation

    • James Westphal
    Ann Intern Med April 3, 2001 134:628

  • Eating Disorders: A Guide to Medical Care and Complications

    • Lynn M. Manfred
    Ann Intern Med April 3, 2001 134:628

Ad Libitum

Book Listings

Medical Notices

Summaries for Patients

  • Too Much Thyroid Hormone Increases Risk for Bone Fractures

    Ann Intern Med April 3, 2001 134:S85

  • The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis

    Ann Intern Med April 3, 2001 134:S93

  • Beta-Blockers Improve Survival and Decrease Hospitalizations in Patients with Heart Failure

    Ann Intern Med April 3, 2001 134:S94

  • Ibopamine: A Drug That Has Opposite Effects Depending on the Severity of a Patient's Disease

    Ann Intern Med April 3, 2001 134:S95
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This Issue

April 3, 2001; 134 (7)
  1. Articles
  2. Brief Communications
  3. Review
  4. Perspectives
  5. Position Papers
  6. Editorial
  7. On Being a Doctor
  8. On Being a Patient
  9. Letters
  10. Medical Writings: Book Notes
  11. Ad Libitum
  12. Book Listings
  13. Medical Notices
  14. Summaries for Patients

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