Osteoarthritis: New Insights. Part 2: Treatment Approaches

  1. Conference Chair: David T. Felson, MD, MPH;
  2. Conference Organizer: Reva C. Lawrence, MPH;
  3. Discussants: Marc C. Hochberg, MD, MPH;
  4. Timothy McAlindon, MD, MPH;
  5. Paul A. Dieppe, MD;
  6. Marian A. Minor, PT, PhD;
  7. Steven N. Blair, PED;
  8. Brian M. Berman, MD;
  9. James F. Fries, MD;
  10. Morris Weinberger, PhD;
  11. Kate R. Lorig, RN, DrPH;
  12. Joshua J. Jacobs, MD; and
  13. Victor Goldberg, MD
  1. From Boston University School of Medicine, Boston, Massachusetts; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland; University of Maryland School of Medicine, Baltimore, Maryland; MRC Health Services Research Collaboration, University of Bristol, Bristol, United Kingdom; University of Missouri, Columbia, Missouri; Cooper Institute for Aerobics Research, Dallas, Texas; Stanford University School of Medicine, Palo Alto, California; Indiana University, Indianapolis, Indiana; Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois; and Case Western Reserve University, Cleveland, Ohio.
    1. Figure 1. The white circles represent the effect size of each glucosamine trial; 0 represents no effect relative to placebo. Horizontal lines represent 95% CIs. The white diamond represents aggregate results (with 95% CI) for glucosamine trials. The black circles and diamonds represent the same features for chondroitin. Data from reference .
      View larger version:
      Figure 1. The white circles represent the effect size of each glucosamine trial; 0 represents no effect relative to placebo. Horizontal lines represent 95% CIs. The white diamond represents aggregate results (with 95% CI) for glucosamine trials. The black circles and diamonds represent the same features for chondroitin. Data from reference . Meta-analysis of placebo-controlled trials of glucosamine and chondroitin in osteoarthritis.48
    2. Figure 2. Pain was measured by using a visual analogue scale in which patients were asked to quantify their current pain. The depression score is derived from Center for Epidemiologic Studies–Depression symptoms scale. Data from reference .
      View larger version:
      Figure 2. Pain was measured by using a visual analogue scale in which patients were asked to quantify their current pain. The depression score is derived from Center for Epidemiologic Studies–Depression symptoms scale. Data from reference . Decreases in pain, depression, and physician visits in 401 patients after 4 months (white bars) and 4 years (shaded bars) of an arthritis self-management program.107
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