Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases

Figure. Computed tomographic scan of patient 4's abdomen, showing diffusely hypodense liver compared with spleen of normal density. These findings are consistent with fatty infiltration. Liver biopsy specimen from patient 1 showing extensive microvesicular and macrovesicular hepatic steatosis (hematoxylin–eosin stain; magnification, ×200). Frozen cross-section of skeletal muscle biopsy sample from patient 4, demonstrating abundant lipid droplets within the muscle fibers (oil red O stain; magnification, ×400). Electron µgraph of skeletal muscle from patient 4, showing subsarcolemmal accumulation of lipids (magnification, ×15 000).
Figure. Computed tomographic scan of patient 4's abdomen, showing diffusely hypodense liver compared with spleen of normal density. These findings are consistent with fatty infiltration. Liver biopsy specimen from patient 1 showing extensive microvesicular and macrovesicular hepatic steatosis (hematoxylin–eosin stain; magnification, ×200). Frozen cross-section of skeletal muscle biopsy sample from patient 4, demonstrating abundant lipid droplets within the muscle fibers (oil red O stain; magnification, ×400). Electron µgraph of skeletal muscle from patient 4, showing subsarcolemmal accumulation of lipids (magnification, ×15 000). Computed tomographic, biopsy, and electron µgraph findings.A.B.C.D.

This Article

  1. Ann Intern Med August 1, 2000 vol. 133 no. 3 192-196
  1. AbstractFREE
  2. Figures
  3. Full Text
  4. Full Text (PDF)

Current Issue

  1. December 1, 2009, 151 (11)
  1. Alert me to current issues