A Systematic Review of Newer Pharmacotherapies for Depression in Adults: Evidence Report Summary: Clinical Guideline, Part 2

  1. John W. Williams, Jr., MD, MHS;
  2. Cynthia D. Mulrow, MD, MSc;
  3. Elaine Chiquette, PharmD;
  4. Polly Hitchcock Noël, PhD;
  5. Christine Aguilar, MD, MPH; and
  6. John Cornell, PhD
  1. From the South Texas Veterans Health Care System, Audie Murphy Division and the San Antonio Evidence-based Practice Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
    1. Figure 1. indicates number of participants; indicates number of studies. GABA = γ-aminobutyric acid; HT = hydroxy-tryptophan; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor.
      View larger version:
      Figure 1. indicates number of participants; indicates number of studies. GABA = γ-aminobutyric acid; HT = hydroxy-tryptophan; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor. Meta-analysis of placebo compared with newer antidepressants for major depression in adults.Nn
    2. Figure 2. . indicates number of participants; indicates number of studies. HT = hydroxy-tryptophan; MAOI = monoamine oxidase inhibitor; NRI = norepinephrine reuptake inhibitor; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor; TCA1 = first-generation tricyclic antidepressant; TCA2 = second-generation tricyclic antidepressant.
      View larger version:
      Figure 2. . indicates number of participants; indicates number of studies. HT = hydroxy-tryptophan; MAOI = monoamine oxidase inhibitor; NRI = norepinephrine reuptake inhibitor; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor; TCA1 = first-generation tricyclic antidepressant; TCA2 = second-generation tricyclic antidepressant. Meta-analysis of older antidepressants compared with newer antidepressants for major depression in adultsNn
    3. Figure 3. indicates number of participants. *Response rates not given. HT = hydroxy-tryptophan; SSRI = selective serotonin reuptake inhibitor.
      View larger version:
      Figure 3. indicates number of participants. *Response rates not given. HT = hydroxy-tryptophan; SSRI = selective serotonin reuptake inhibitor. Meta-analysis of newer antidepressants for dysthymia in adults.N
    4. Figure 4. indicates number of participants. The diamonds represent a summary estimate, derived from the individual studies listed above the diamonds. The center of each diamond is the point estimate, and the tails represent the 95% CIs.
      View larger version:
      Figure 4. indicates number of participants. The diamonds represent a summary estimate, derived from the individual studies listed above the diamonds. The center of each diamond is the point estimate, and the tails represent the 95% CIs. Meta-analysis of hypericum (St. John's wort) for depressive disorders in adults.N
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    1. Ann Intern Med May 2, 2000 vol. 132 no. 9 743-756
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