Table of Contents

May 2, 2000; 132 (9)

Articles

  • Postmenopausal Hormone Therapy Increases Risk for Venous Thromboembolic Disease: The Heart and Estrogen/progestin Replacement Study

    • Deborah Grady,
    • Nanette K. Wenger,
    • David Herrington,
    • Steven Khan,
    • Curt Furberg,
    • Donald Hunninghake,
    • Eric Vittinghoff,
    • Stephen Hulley,
    • and for the Heart and Estrogen/progestin Replacement Study Research Group
    Ann Intern Med May 2, 2000 132:689-696

    Postmenopausal therapy with estrogen plus progestin increases risk for venous thromboembolism in women with coronary heart disease. This risk should be considered when the risks and benefits of therapy are being weighed.

  • Screening for Cervical and Breast Cancer: Is Obesity an Unrecognized Barrier to Preventive Care?

    • Christina C. Wee,
    • Ellen P. McCarthy,
    • Roger B. Davis,
    • and Russell S. Phillips
    Ann Intern Med May 2, 2000 132:697-704

    Compared with normal-weight women, overweight and obese women were less likely to be screened for cervical and breast cancer with Papanicolaou smears and mammography, even after adjustment for other known barriers to care. Because overweight and obese women have higher rates of death from cervical and breast cancer, they should be targeted for increased screening.

  • Determining the Quality of Breast Cancer Care: Do Tumor Registries Measure Up?

    • Nina A. Bickell and
    • Mark R. Chassin
    Ann Intern Med May 2, 2000 132:705-710

    Data from tumor registries were found to provide accurate measures for hospital-based surgical treatments but not for outpatient treatment. Unverified tumor registry data should not be used to measure quality of care.

Brief Communications

  • Hyponatremia, Cerebral Edema, and Noncardiogenic Pulmonary Edema in Marathon Runners

    • J. Carlos Ayus,
    • Joseph Varon,
    • and Allen I. Arieff
    Ann Intern Med May 2, 2000 132:711-714

    In seven healthy marathon runners, noncardiogenic pulmonary edema was associated with hyponatremic encephalopathy. The condition may be fatal if it is not diagnosed, and it can be successfully treated with hypertonic NaCl.

Academia and Clinic

  • Claims of Equivalence in Medical Research: Are They Supported by the Evidence?

    • William L. Greene,
    • John Concato,
    • and Alvan R. Feinstein
    Ann Intern Med May 2, 2000 132:715-722

    Many studies of clinical equivalence do not set boundaries for equivalence. Claims of “difference” or “similarity” are often made not by thoughtful examination of the data but by tests of statistical significance that are frequently misapplied or accompanied by inadequate sample sizes. These methodologic flaws can lead to false claims, inconsistencies, and harm to patients.

Review

  • Chronic Hepatitis B Virus Infection: Treatment Strategies for the Next Millennium

    • Arshad H. Malik and
    • William M. Lee
    Ann Intern Med May 2, 2000 132:723-731

    This review focuses on specific treatments available for hepatitis B and discusses the replication of the hepatitis B virus to facilitate understanding of the mechanism of action of nucleoside analogues.

Position Papers

  • Pharmacologic Treatment of Acute Major Depression and Dysthymia: Clinical Guideline, Part 1

    • Vincenza Snow,
    • Steven Lascher,
    • Christel Mottur-Pilson,
    • and for the American College of Physicians-American Society of Internal Medicine*.
    Ann Intern Med May 2, 2000 132:738-742

    This guideline answers the following questions: What evidence supports the benefits of pharmacologic treatment of depression? What are the data on the efficacy and side effects of newer compared with older pharmacotherapies? How can the evidence assist physicians and patients in making informed decisions about treatment options?

  • A Systematic Review of Newer Pharmacotherapies for Depression in Adults: Evidence Report Summary: Clinical Guideline, Part 2

    • John W. Williams, Jr.,
    • Cynthia D. Mulrow,
    • Elaine Chiquette,
    • Polly Hitchcock Noël,
    • Christine Aguilar,
    • and John Cornell
    Ann Intern Med May 2, 2000 132:743-756

    Newer antidepressants are clearly effective for treating depressive disorders in diverse settings. Because of similar efficacy, both newer and older antidepressants should be considered when treatment decisions are being made. Better information is urgently needed on the efficacy of newer antidepressants in patients with nonmajor depression and in special populations.

Editorials

  • What Is the Right Cancer Screening Rate?

    • Russell Harris
    Ann Intern Med May 2, 2000 132:732-734

    The study by Wee and colleagues in this issue highlights the need for new approaches to assessing quality of care.

  • The Role of Bisphosphonates in Multiple Myeloma

    • Robert A. Kyle
    Ann Intern Med May 2, 2000 132:734-736

    Multiple myeloma is a difficult and frustrating disease to treat. Although bisphosphonates are clearly not a panacea, they represent an advance in skeletal benefit and symptom control that is meaningful for both patients and physicians.

On Being a Doctor

  • Simple Gifts

    • Christine S. Seibert
    Ann Intern Med May 2, 2000 132:757

    Sometimes, after a particularly difficult day, I sift through my box to be reminded and sustained by these special encounters in my journey as a physician.

Letters

  • Risk for Obstructive Sleep Apnea

    • Frank Tamarin and
    • Robert D. Brandstetter
    Ann Intern Med May 2, 2000 132:758

  • Risk for Obstructive Sleep Apnea

    • David A. Nardone
    Ann Intern Med May 2, 2000 132:758

  • Risk for Obstructive Sleep Apnea

    • Ronald S. Strauss and
    • Warren S. Browner
    Ann Intern Med May 2, 2000 132:758-759

  • Risk for Obstructive Sleep Apnea

    • Nikolaus C. Netzer and
    • Kingman P. Strohl
    Ann Intern Med May 2, 2000 132:759

  • Nonfasting Plasma Total Homocysteine Level and Mortality

    • Mark D. Eisner
    Ann Intern Med May 2, 2000 132:759-760

  • Nonfasting Plasma Total Homocysteine Level and Mortality

    • Jeremy D. Kark,
    • Joseph H. Abramson,
    • and Irwin H. Rosenberg
    Ann Intern Med May 2, 2000 132:760

  • Therapeutic Plasma Exchange

    • Fadi Fakhouri,
    • François Vincent,
    • and Christophe Legendre
    Ann Intern Med May 2, 2000 132:760

  • Therapeutic Plasma Exchange

    • William F. Clark,
    • Gail Rock,
    • and Kenneth A. Shumak
    Ann Intern Med May 2, 2000 132:760-761

  • Quotations on the Wall

    • Harish Jasti
    Ann Intern Med May 2, 2000 132:761

  • Potential New Cardiovascular Risk Factors

    • Bruce L. Rollman,
    • Peter F. Counihan,
    • and Charles F. Reynolds
    Ann Intern Med May 2, 2000 132:761

  • Serum Cholesterol and Low-Density Lipoprotein Cholesterol Levels as Predictors of Response to Interferon Therapy for Chronic Hepatitis C

    • Gerald Y. Minuk,
    • Sharon Weinstein,
    • and Kelly D. Kaita
    Ann Intern Med May 2, 2000 132:761-762

  • Small Dense Low-Density Lipoprotein in Japanese Men with Coronary Artery Disease

    • Shinji Koba and
    • Tsutomu Hirano
    Ann Intern Med May 2, 2000 132:762

Medical Writings

  • Error in Medicine: What Have We Learned?

    • David W. Bates and
    • Atul A. Gawande
    Ann Intern Med May 2, 2000 132:763-767

    This essay discusses several books on the continuing discovery of the frequency and effect of medical errors.

Medical Writings: Book Notes

  • Evidence-Based Clinical Practice: Concepts and Approaches

    • Eleanor Z. Wallace
    Ann Intern Med May 2, 2000 132:768

  • Medical Quality Management Sourcebook, 2000 Edition: A Comprehensive Guide to Standardizing Quality Measurement and Improving Care

    • Patrick S. Romano
    Ann Intern Med May 2, 2000 132:768

Ad Libitum

Book Listings

Medical Notices

  • Medical Notices

    Ann Intern Med May 2, 2000 132:0

Summaries for Patients

  • Postmenopausal Hormone Replacement and the Risk for Blood Clots

    Ann Intern Med May 2, 2000 132:689

  • Is Obesity a Barrier to Screening for Cervical and Breast Cancer?

    Ann Intern Med May 2, 2000 132:697

  • Are Tumor Registries a Good Way To Measure the Quality of Breast Cancer Care?

    Ann Intern Med May 2, 2000 132:705

  • Serious Fluid Accumulation in the Brain and Lungs of Marathon Runners

    Ann Intern Med May 2, 2000 132:711
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This Issue

May 2, 2000; 132 (9)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Position Papers
  6. Editorials
  7. On Being a Doctor
  8. Letters
  9. Medical Writings
  10. Medical Writings: Book Notes
  11. Ad Libitum
  12. Book Listings
  13. Medical Notices
  14. Summaries for Patients

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