Screening for Hereditary Hemochromatosis in Siblings and Children of Affected Patients: A Cost-Effectiveness Analysis
- Hashem B. El-Serag, MD, MPH;
- John M. Inadomi, MD; and
- Kris V. Kowdley, MD
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From Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; Ann Arbor Veterans Affairs Medical
Center and University of Michigan Medical Center, Ann Arbor, Michigan; and University of Washington, Seattle, Washington.
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Figure 1. Plus signs indicate a positive test result; minus signs indicate a negative test result. The asterisk indicates
that this strategy applies only to the children of a proband. All illustrated probabilities apply only to children. A decision-analytic model comparing the costs incurred by no screening with four strategies to screen relatives of an affected
patient with hereditary hemochromatosis.
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Figure 2. Plus signs indicate a positive test result; minus signs indicate a negative test result. Algorithm for screening siblings or children of a proband with hereditary hemochromatosis by usingHFEgene testing.
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Figure 3. The solid lines with circles represents gene testing children first, the dashed line with circles represents gene
testing the proband first, the solid line with squares represents serum iron studies, and the solid line with triangles represents
gene testing the spouse. Screening of children for hereditary hemochromatosis.
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Figure 4. The dashed line with circles represents gene testing the proband first, the solid line with squares represents serum
iron studies, and the solid line with circles represents gene testing siblings first. Screening of siblings for hereditary hemochromatosis.
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Figure 5. . The cost of screening a combination of relatives for hereditary hemochromatosis
- Copyright ©2004 by the American College of Physicians
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Ann Intern Med
February 15, 2000
vol. 132
no. 4
261-269
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Figure 1. Plus signs indicate a positive test result; minus signs indicate a negative test result. The asterisk indicates that this strategy applies only to the children of a proband. All illustrated probabilities apply only to children. A decision-analytic model comparing the costs incurred by no screening with four strategies to screen relatives of an affected patient with hereditary hemochromatosis.
Figure 2. Plus signs indicate a positive test result; minus signs indicate a negative test result. Algorithm for screening siblings or children of a proband with hereditary hemochromatosis by usingHFEgene testing.
Figure 3. The solid lines with circles represents gene testing children first, the dashed line with circles represents gene testing the proband first, the solid line with squares represents serum iron studies, and the solid line with triangles represents gene testing the spouse. Screening of children for hereditary hemochromatosis.
Figure 4. The dashed line with circles represents gene testing the proband first, the solid line with squares represents serum iron studies, and the solid line with circles represents gene testing siblings first. Screening of siblings for hereditary hemochromatosis.
Figure 5. . The cost of screening a combination of relatives for hereditary hemochromatosis
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