Table of Contents

August 3, 1999; 131 (3)

Articles

  • Social engagement, defined as the maintenance of many social connections and a high level of participation in social activities, has been thought to prevent cognitive decline in elderly persons. In a large group of noninstitutionalized elderly patients, social disengagement was found to be a risk factor for cognitive impairment.

  • Among patients with chronic hepatitis C, interferon therapy significantly reduced the risk for hepatocellular carcinoma, especially in persons who showed a virologic or biochemical response.

  • The addition of metformin to insulin therapy resulted in hemoglobin A1c concentrations that were lower than those achieved by insulin therapy alone. This improvement in glycemic control occurred with the use of less insulin and without substantial weight gain.

Brief Communications

  • Previous endometrial or ovarian cancer, particularly when diagnosed at an early age, increases subsequent risk for colorectal cancer. Greater emphasis on colorectal cancer screening in these populations may be necessary.

  • Many patients with HIV have a strong will to live, and many feel that life with HIV is better than it was before they became infected.

Review

  • Chronic myelogenous leukemia is one of the best-studied malignant conditions in humans. Progress in the understanding of molecular pathways has led to increasingly targeted and effective treatments, including allogeneic stem-cell transplantation and interferon-α.

Editorial

  • In this issue, Bassuk and colleagues report modest associations between social ties and cognitive decline in elderly persons. Decline in elderly persons is complex and multifactorial; at best, medical treatment of complicated cases merely ameliorates the problems. Bassuk and colleagues' findings suggest that in such cases, the simple act of caring may be enough to slow the long slide into dementia.

On Being a Doctor

  • O.U. School of Medicine, class of 1945. My mother is one of only three women in the sepia-toned photograph. “How come you never worked as a doctor, Mama?” I asked frequently.

On Being a Patient

  • It is the first day of my surgery clerkship. After a frantic race to a patient in crisis, my shortness of breath blossoms into an exercise-induced asthma attack. Despite my assertions that I am fine, I soon find myself admitted to the hospital.

Letters

Medical Writings

  • In the past 12 years, four books have addressed the issues of the changing setting and nature of the patient–physician relationship. They have also tackled the even more difficult problem of defining the relationship and identifying its essential components. These books show the way to start on the road of educating young physicians to become caring physicians, but they do not have the final answers.

Medical Writings: Book Notes

Ad Libitum

Book Listings

Medical Notices

Updates from the Annual Session

  • The 1999–2000 Update Series begins with a discussion of important studies relevant to general internal medicine. Among the subject areas covered are cancer, stroke, venous thromboembolism, and osteoporosis.