Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management

Figure 1. Intermingling of adrenocortical and chromaffin tissue. Chromaffin cells are immunostained red with antibodies to chromogranin A (Clone Dako A3, Dako, Copenhagen, Denmark; original magnification, ×200). Endothelial cells immunostained with antibodies to CD31 (Dako) ( ) are in direct contact with adrenocortical cells in the zona fasciculata ( ). The reaction was visualized with 3-amino-ethylcarbasole (original magnification, ×800). Electron µgraph of a nerve cell ( ) in apposition with an adrenocortical cell. The latter shows vesicular mitochondria ( ) and extends filopodia ( ) to the nerve cell. Scale, 0.5 µm. Electron µgraph of a macrophage in direct contact with adrenocortical cells. Macrophages show lysosomes ( ), rough endoplasmic reticulum ( ), and pinocytotic vesicles ( ). Adrenocortical cells have ample mitochondria with characteristic vesicular internal membranes, smooth endoplasmic reticulum, and Golgi complex ( ). Scale, 1 µm. NUC = nucleus.
Figure 1. Intermingling of adrenocortical and chromaffin tissue. Chromaffin cells are immunostained red with antibodies to chromogranin A (Clone Dako A3, Dako, Copenhagen, Denmark; original magnification, ×200). Endothelial cells immunostained with antibodies to CD31 (Dako) ( ) are in direct contact with adrenocortical cells in the zona fasciculata ( ). The reaction was visualized with 3-amino-ethylcarbasole (original magnification, ×800). Electron µgraph of a nerve cell ( ) in apposition with an adrenocortical cell. The latter shows vesicular mitochondria ( ) and extends filopodia ( ) to the nerve cell. Scale, 0.5 µm. Electron µgraph of a macrophage in direct contact with adrenocortical cells. Macrophages show lysosomes ( ), rough endoplasmic reticulum ( ), and pinocytotic vesicles ( ). Adrenocortical cells have ample mitochondria with characteristic vesicular internal membranes, smooth endoplasmic reticulum, and Golgi complex ( ). Scale, 1 µm. NUC = nucleus. Histologic characteristics of the normal human adrenal gland. A.B.arrowsZFC.NERVMITarrowsD.LYRERarrowsGolgi

This Article

  1. Ann Intern Med May 4, 1999 vol. 130 no. 9 759-771
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