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Rapid Recovery of Bone Mass in Hypercalciuric, Osteoporotic Men Treated with Hydrochlorothiazide
- John S. Adams, MD;
- Cindy F. Song, BS; and
- Vitaly Kantorovich, MD
- From Burns and Allen Research Institute and Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine, Los Angeles, California.
Abstract
Background: Chronic hypercalciuria can contribute to osteoporosis, particularly in men.
Objective: To ascertain the effects of resolution of hypercalciuria on bone mineral density.
Design: Case series.
Setting: Referral service for metabolic bone disease in a tertiary-care teaching hospital.
Patients: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.
Intervention: Hydrochlorothiazide, 25 mg twice daily, for a mean (± SD) of 7.8 ± 3.6 months.
Measurements: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.
Results: Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.
Conclusions: Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.
Article and Author Information
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Grant Support: In part by grant MO1-RR00425 from the National Center for Research Resources and the National Institutes of Health General Clinical Research Center.
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Requests for Reprints: John S. Adams, MD, B-131, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048; e-mail, adamsj{at}cshs.org.
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Current Author Addresses: Dr. Adams: B-131, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.
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Ms. Song: 491 11th Avenue, San Francisco, CA 94118.
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Dr. Kantorovich: B-131, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.
- Copyright ©2004 by the American College of Physicians
