An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome

Figure 5. A spectrum of clinical presentations is seen among the affected family members; some exhibit lymphoproliferation, increased double-negative T cells, and autoimmunity. One member developed lymphoma. The squares represent males; the circles represent females; the arrow identifies the proband; and the slash identifies a family member who died. Reproduced with permission from Infante and colleagues .
Figure 5. A spectrum of clinical presentations is seen among the affected family members; some exhibit lymphoproliferation, increased double-negative T cells, and autoimmunity. One member developed lymphoma. The squares represent males; the circles represent females; the arrow identifies the proband; and the slash identifies a family member who died. Reproduced with permission from Infante and colleagues . A kindred of 11 persons in four generations with a mutation in the death domain of Fas.(8)

This Article

  1. Ann Intern Med April 6, 1999 vol. 130 no. 7 591-601
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