An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome

Figure 2. Spanning the cell membrane are Fas (CD95) and tumor necrosis factor 1 ( ) molecules. Each functions in homotrimers to bind ligands (Fas ligand and TNF, respectively) and trigger apoptosis. Cytoplasmic adapter molecules (FADD/MORT-1) bind the similar death domains of each receptor and then form complexes with caspase 8, which is cleaved to activate other caspase enzymes that ultimately mediate degradation of cellular DNA, cell death, and disintegration. FADD = Fas-associated death domain protein; FLICE/MACH 1 = FADD-like interleukin-1-converting enzyme/mediator of receptor-induced toxicity 1; NF-κB = nuclear factor-κB; RIP = receptor interacting protein; TRADD = TNF receptor-associated death domain protein; TRAF 2 = TNF receptor-associated factor 2.
Figure 2. Spanning the cell membrane are Fas (CD95) and tumor necrosis factor 1 ( ) molecules. Each functions in homotrimers to bind ligands (Fas ligand and TNF, respectively) and trigger apoptosis. Cytoplasmic adapter molecules (FADD/MORT-1) bind the similar death domains of each receptor and then form complexes with caspase 8, which is cleaved to activate other caspase enzymes that ultimately mediate degradation of cellular DNA, cell death, and disintegration. FADD = Fas-associated death domain protein; FLICE/MACH 1 = FADD-like interleukin-1-converting enzyme/mediator of receptor-induced toxicity 1; NF-κB = nuclear factor-κB; RIP = receptor interacting protein; TRADD = TNF receptor-associated death domain protein; TRAF 2 = TNF receptor-associated factor 2. Mediators of lymphocyte apoptosis.TNFR1

This Article

  1. Ann Intern Med April 6, 1999 vol. 130 no. 7 591-601
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