An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome

Figure 1. Frontal view of National Institutes of Health patient 2. (Reproduced with permission from Sneller and colleagues .) Lymph node from patient 2 showing follicular hyperplasia and plasmacytosis (hematoxylin and eosin). (Courtesy of Dr. Elaine Jaffe.) Immunohistochemical stain of patient 2's lymph node for cells showing lymphocyte surface marker CD3. (Courtesy of Dr. Elaine Jaffe.) Immunohistochemical stain of patient 2's lymph node for cells showing lymphocyte surface marker CD4. (Courtesy of Dr. Elaine Jaffe.) Immunohistochemical stain of patient 2's lymph node for cells showing lymphocyte surface marker CD8. Few of the cells that stain reddish brown for CD3 are CD4 or CD8 . (Courtesy of Dr. Elaine Jaffe.) Computed tomographic scan through the upper thorax and axillae and abdomen of patient 23 showing marked paratracheal, anterior mediastinal, and axillary adenopathy. (Courtesy of Dr. Nilo Avila.) Computed tomographic scan through the upper thorax and axillae and abdomen of patient 23 showing hepatosplenomegaly. (Courtesy of Dr. Nilo Avila.) For panels B to E, original magnifications were ×200. For panels C to E, the stain used was immunoperoxidase.
Figure 1. Frontal view of National Institutes of Health patient 2. (Reproduced with permission from Sneller and colleagues .) Lymph node from patient 2 showing follicular hyperplasia and plasmacytosis (hematoxylin and eosin). (Courtesy of Dr. Elaine Jaffe.) Immunohistochemical stain of patient 2's lymph node for cells showing lymphocyte surface marker CD3. (Courtesy of Dr. Elaine Jaffe.) Immunohistochemical stain of patient 2's lymph node for cells showing lymphocyte surface marker CD4. (Courtesy of Dr. Elaine Jaffe.) Immunohistochemical stain of patient 2's lymph node for cells showing lymphocyte surface marker CD8. Few of the cells that stain reddish brown for CD3 are CD4 or CD8 . (Courtesy of Dr. Elaine Jaffe.) Computed tomographic scan through the upper thorax and axillae and abdomen of patient 23 showing marked paratracheal, anterior mediastinal, and axillary adenopathy. (Courtesy of Dr. Nilo Avila.) Computed tomographic scan through the upper thorax and axillae and abdomen of patient 23 showing hepatosplenomegaly. (Courtesy of Dr. Nilo Avila.) For panels B to E, original magnifications were ×200. For panels C to E, the stain used was immunoperoxidase. Clinical, radiologic, and histologic features of patients with the autoimmune lymphoproliferative syndrome. A.[6]B.C.D.E.++F.G.

This Article

  1. Ann Intern Med April 6, 1999 vol. 130 no. 7 591-601
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