Recent Advances in Varicella-Zoster Virus Infection

Figure 3. / Although intracellular drug triphosphate concentrations are more relevant, this schematic provides some explanation for the advantages of intravenous acyclovir ( ), oral valacyclovir ( ), and oral famciclovir ( ) relative to standard high-dose (800 mg) oral acyclovir ( ). id = per day; IV = intravenous; PO = oral; Q8h = every 8 hours.
Figure 3. / Although intracellular drug triphosphate concentrations are more relevant, this schematic provides some explanation for the advantages of intravenous acyclovir ( ), oral valacyclovir ( ), and oral famciclovir ( ) relative to standard high-dose (800 mg) oral acyclovir ( ). id = per day; IV = intravenous; PO = oral; Q8h = every 8 hours. Approximate peak serum blood levels of antiviral drugs and the 50% effective dose (ED50) in vitro concentrations required to inhibit replication of the herpes simplex virus (HSV) or the varicella-zoster virus (VZV).ACVVCVFCVACV

This Article

  1. Ann Intern Med June 1, 1999 vol. 130 no. 11 922-932
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