Acute HIV Syndrome after Discontinuation of Antiretroviral Therapy in a Patient Treated before Seroconversion
- Eric S. Daar, MD;
- Jiexin Bai, MD;
- Mary Ann Hausner, MS;
- Martin Majchrowicz, MPH;
- Mojgan Tamaddon, BA; and
- Janis V. Giorgi, PhD
- From Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California. Acknowledgments: The authors thank Stephen Nichols, MD, for technical assistance; Jacqui Pitt, RN, for clinical assistance; Marie Reskusic for figure preparation; and John Ferbas, PhD, for critical review of the manuscript. They also thank the patient, who cooperated with all studies and reviewed the manuscript to assure accuracy of the description of the clinical syndrome. Grant Support: In part by the Universitywide AIDS Research Program California Multicenter AIDS Research Consortium Award and National Institutes of Health grant AI-32883. Requests for Reprints: Eric S. Daar, MD, Division of Infectious Diseases, Cedars-Sinai Medical Center, B217, 8700 Beverly Boulevard, Los Angeles, CA 90048. Current Author Addresses: Drs. Daar and Bai and Ms. Tamaddon: Division of Infectious Diseases, Cedars-Sinai Medical Center, B217, 8700 Beverly Boulevard, Los Angeles, CA 90048.
Primary HIV infection is associated with high levels of viral replication and the development of HIV-specific immune responses [1-5]. Treating patients during primary HIV infection is recommended [6], but little is known about the effects of such therapy [7-9]. We report the results of virologic and immunologic studies in a patient who began receiving antiretroviral therapy during primary HIV infection and chose to discontinue therapy after 6 months.
Case Report
A 38-year-old homosexual man presented on day 5 of an acute retroviral syndrome characterized by fever, pharyngitis, myalgia, headache, lymphadenopathy, and rash. The patient's leukocyte count was 2.6 × 109/L, his platelet count was 85.0 × 109/L, and his plasma HIV RNA level was 1 800 000 copies/mL. No HIV antibodies were detectable. Primary HIV infection was diagnosed. Infection was probably a result of a receptive orogenital sexual encounter that took place 13 days before presentation, when the patient had a hard-palate ulcer. …
This 100-word excerpt has been provided in the absence of an abstract.
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