Thrombopoietin: Platelets on Demand
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TO THE EDITOR:
In his incisive editorial on the identification and cloning of thrombopoietin [1], Dr. Kaushansky implies that James H. Wright first observed blood plates (platelets) in 1906. This discovery is usually attributed to Alexandre Donne, distinguished French microscopist, who in 1842 described platelets as a third blood particle. Later investigators who more fully described the platelets and their function include Max Schultze (1865), William Osler (1873), Georges Hayem1875, and Giulio Bizzozero (1883). To James H. Wright goes the distinction of the 1906 discovery of the role of the megakaryocyte in the production of platelets.
Richard L. Golden, MD
State University of New York at Stony Brook School of Medicine Stony Brook, NY 11794
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
- Copyright ©2004 by the American College of Physicians
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