Warfarin: Less May Be Better
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TO THE EDITOR:
I understand the need for “brief communications,” but there is such a thing as too brief. Harrison and colleagues' interesting article [1] comparing different loading doses of warfarin leaves out some essential information. How are we to assess the generalizability of the results when so little information is provided about the patients in the trial? How old were they? What were the indications for anticoagulation? What other medical problems did the patients have? More important, the authors note that after the initial dose. “subsequent doses were determined on the basis of nomograms that were developed before the study began through an iterative process.” Wouldn't it be appropriate to share the details of these nomograms with the readers?
Carl D. Atkins, MD
South Shore Hematology-Oncology Associates; Rockville Centre, NY 11570
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
- Copyright ©2004 by the American College of Physicians
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