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Warfarin: Less May Be Better
- Saint Vincent Health Center; Erie, PA 16502 Requests for Reprints: Michael A. LaCombe, MD, 103 South High Street, Bridgton, ME 04009.
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TO THE EDITOR:
Harrison and colleagues [1] compared 10-mg and 5-mg loading doses of warfarin. Subsequent doses were determined by nomograms. Most physicians would consider the loading dose to be the dose or doses given over the first few days or until an end point had been reached (for example, an international normalized ratio [INR] of 2 to 3). It would be useful to know what the nomograms were to better evaluate the effect of the “loading dose” versus subsequent doses on the data.
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
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