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Folic Acid and Methotrexate in Rheumatoid Arthritis
- Sarah L. Morgan, MD, RD;
- Jeannette Y. Lee, PhD; and
- Graciela S. Alarcon, MD, MPH
- University of Alabama at Birmingham; Birmingham, AL 35294
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IN RESPONSE:
Dr. Cooper questions the statistical validity of our conclusions regarding the effect of folic acid supplementation on the efficacy of methotrexate. Our sample size and power calculations were based on the toxicity data, which were the primary outcome of the study. We could not show any difference in the efficacy of methotrexate among the three treatment groups. Although Dr. Cooper is correct that we might not have had adequate power to …
