Insulin-like Growth Factors and Cancer
- Derek LeRoith, MD, PhD;
- Renato Baserga, MD, PhD;
- Lee Helman, MD; and
- Charles T. Roberts Jr., MD
- An updated summary of a conference held 23 February 1994 at the National Institutes of Health, Bethesda, Maryland. Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of reference: Baserga R. The role of insulin-like growth factor 1 receptor in cell growth and transformation, pp 54-55. In: LeRoith D, moderator. Insulin-like growth factors and cancer. Ann Intern Med. 1995; 122:54-59. Requests for Reprints: Derek LeRoith, MD, Molecular and Cellular Physiology Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8S-239, Bethesda, MD 20892.
Abstract
The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.
- Copyright ©2004 by the American College of Physicians
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